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diagnosis differential lfts management bilirubin causes tests abnormal aflp algorithm alkaline alkphos alp astalt biliary chemistry cholangitis cirrhosis elevated endocrinology
Bilirubin Metabolism - Pathophysiology • Conjugated Bilirubin • Unconjugated Bilirubin By Dr. Khushboo Gala @LouLectures #Bilirubin #Metabolism #Pathophysiology
Bilirubin Metabolism ... - Pathophysiology ... #Bilirubin #Metabolism ... #Pathophysiology ... #hepatology #Liver
Functions of the Liver Storage Degradation Metabolism Synthesis #Pathophysiology #Functions #Liver #Hepatology #Synthesis #Storage #Metabolism
Functions of the Liver ... Synthesis #Pathophysiology ... #Functions #Liver ... #Hepatology #Synthesis ... #Storage #Metabolism
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
Elevated Liver Function ... : • Genetic/Metabolic ... (Drug-induced liver ... Differential #Diagnosis #hepatology ... #transaminitis
Elevated Transaminases / Transaminitis - Differential Diagnosis • Infectious: HAV, HCV, HEV, EBV, HSV, CMV •
Transaminases / Transaminitis ... Trauma: Shock liver ... • Metabolic: ... images/10587 #Transaminitis ... Diagnosis #causes #hepatology
Patterns of Liver Injury Transaminase Levels: > 50x normal - Ischemic Hepatitis > 20x normal
Patterns of Liver ... NASH, Genetic / Metabolic ... #Patterns #Liver ... #Injury #hepatology ... #LFTs #transaminitis
Acute Fatty Liver of Pregnancy (AFLP) Pathophysiology: • Defect in fetal free fatty acid metabolism products →
Pregnancy (AFLP) Pathophysiology ... free fatty acid metabolism ... Intermediate fatty acid metabolism ... #Pregnancy #hepatology ... diagnosis #management #pathophysiology
Liver Chemistry Tests - AST, ALT, Alkaline Phosphatase and Bilirubin Metabolism AST and ALT: • AST: liver
and Bilirubin Metabolism ... insult Bilirubin metabolism ... Tests #Laboratory #Metabolism ... AlkPhos #Bilirubin #Hepatology ... #Pathophysiology
Feedback Loop: Growth Hormone (GH) Growth Hormone: • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
Growth Hormone: • Liver ... activates lipolysis Signs ... thickness) - metabolic ... endocrinology #pathophysiology
Abnormal liver function tests algorithm. This figure details the initial response to abnormal liver blood tests.
Abnormal liver function ... derangement of liver ... clinical symptoms/signs ... The presence of metabolic ... Abnormal #Algorithm #Hepatology
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
65 years PBC Pathophysiology ... cholestasis → Cirrhosis/Liver ... failure PBC Signs ... or higher • Liver ... diagnosis #workup #hepatology
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