25 results
Bilirubin Metabolism - Pathophysiology
 • Conjugated Bilirubin
 • Unconjugated Bilirubin

By Dr. Khushboo Gala @LouLectures

#Bilirubin #Metabolism #Pathophysiology
Bilirubin Metabolism ... - Pathophysiology ... #Bilirubin #Metabolism ... #Pathophysiology ... #hepatology #Liver
Functions of the Liver

Storage 
Degradation 
Metabolism 
Synthesis 

#Pathophysiology #Functions #Liver #Hepatology #Synthesis #Storage #Metabolism
Functions of the Liver ... Synthesis #Pathophysiology ... #Functions #Liver ... #Hepatology #Synthesis ... #Storage #Metabolism
Liver Chemistry Tests - AST, ALT, Alkaline Phosphatase and Bilirubin Metabolism
AST and ALT:
 • AST: liver
and Bilirubin Metabolism ... insult Bilirubin metabolism ... #ASTALT #AlkPhos ... #Bilirubin #Hepatology ... #Pathophysiology
Patterns of Liver Injury
Transaminase Levels:
  > 50x normal - Ischemic Hepatitis
  > 20x normal
Patterns of Liver ... NASH, Genetic / Metabolic ... By AST:ALT Ratio ... #Patterns #Liver ... #Injury #hepatology
Acute Fatty Liver of Pregnancy (AFLP)
Pathophysiology:
 • Defect in fetal free fatty acid metabolism products →
Pregnancy (AFLP) Pathophysiology ... free fatty acid metabolism ... Intermediate fatty acid metabolism ... #Pregnancy #hepatology ... diagnosis #management #pathophysiology
Feedback Loop: Growth Hormone (GH)
Growth Hormone:
 • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
Growth Hormone: • Liver ... activates JAK-STAT ... activates lipolysis Signs ... thickness) - metabolic ... endocrinology #pathophysiology
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm
DILI suspicion
Features toxic aetiology: Skin involvement, Kidney injury,
Drug Induced Liver ... drugs, OTC (record start ... non-essential drug/HDS treatments ... Alcohol-related liver ... Diagnosis #Algorithm #hepatology
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
Acute Liver Injury ... Causes of Acute Liver ... • Metabolic/Hereditary ... be abnormal AST ... diagnosis #algorithm #hepatology
Refeeding Syndrome: Pathogenesis and clinical findings

Patients at Risk of Refeeding Syndrome:
 - Little or no nutritional
glucose, fluid, salt ... • Incr Glucose Metabolism ... Syndrome - Metabolic ... Syndrome #diagnosis #pathophysiology ... #symptoms #signs
Abnormal liver function tests algorithm.
 This figure details the initial response to abnormal liver blood tests.
Abnormal liver function ... derangement of liver ... clinical symptoms/signs ... The presence of metabolic ... Abnormal #Algorithm #Hepatology