16 results
Tranexamic Acid - Indications and Pharmacology
Pharmacokinetics:
 • MOA: Inhibits plasminogen activation to plasmin & inhibits fibrinolysis
Indications and Pharmacology ... angioedema) • Metabolism ... amount of hepatic metabolism ... #Indications #Pharmacology ... #hematology
Peri-operative Hyperthermia - Guidelines for Crises in Anaesthesia
If prolonged or ≥ 39 C this is a
dissipation of metabolic ... maintained fever CAUSES ... hyperthermia crisis (late sign ... #Differential #Causes ... Anesthesiology #Anesthesia
Feedback Loop: Growth Hormone (GH)
Growth Hormone:
 • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
activates lipolysis Signs ... thickness) - metabolic ... #FeedbackLoop #endocrinology ... #pathophysiology
Phenylephrine - Anesthesia Pharmacology
Trade Name: Phenylephrine
Brand Name(s): Neo-Synephrine
Drug Type: α-1 Agonist
Time of Onset: Rapid
Duration of Action:
Phenylephrine - Anesthesia ... Pharmacology Trade ... Action: Hepatic metabolism ... NeoSynephrine #Anesthesia ... #Pharmacology
Acute Fatty Liver of Pregnancy (AFLP)
Pathophysiology:
 • Defect in fetal free fatty acid metabolism products →
Pregnancy (AFLP) Pathophysiology ... free fatty acid metabolism ... Intermediate fatty acid metabolism ... = nonspecific (nausea ... Liver #Pregnancy #hepatology
Hypothyroid Myopathy
Very common (up to 80% ) in patients with hypothyroidism
Pathophysiology:
 • T4 deficiency leads to
hypothyroidism Pathophysiology ... mitochondrial oxidative metabolism ... Hypothyroid #Myopathy #pathophysiology ... #signs #symptoms ... #endocrinology
Diabetic Ketoacidosis (DKA) - Pathogenesis and Clinical Findings
 • Note: in DKA, body K+ is lost
out of cells may cause ... Due to neuronal metabolism ... Signs/Symptoms/Complications ... DiabeticKetoacidosis #DKA #pathophysiology ... #endocrinology
Malignant Hyperthermia Crisis - Guidelines for Crises in Anaesthesia
Unexplained increase in ETCO2 AND tachycardia AND increased
in Anaesthesia ... rise is a late sign ... other, more common causes ... amiodarone/metoprolol Metabolic ... Anesthesiology #Anesthesia
Causes of Secondary Hypertension - Workup and Differential Diagnosis
Approach (when evaluation should be done):
1. Severe or
Causes of Secondary ... hypertension and signs ... hypokalemia and metabolic ... renal bruit or signs ... Vasculitis • Endocrinologic
Cushing's Syndrome - Hypercortisolism - Diagnosis and Clinical Features
1) Skin
 • Thin, easily bruisable skin with
, oral cavity) Caused ... Endocrine and metabolic ... hypernatremia, metabolic ... Hypercortisolism #Diagnosis #signs ... #symptoms #endocrinology