79 results
Metformin Associated Lactic Acidosis (MALA) 

Pathophysiology of MALA
 - Metformin interferes with the activity of the
(MALA) Pathophysiology ... use in cellular metabolism ... via anaerobic metabolism ... includes symptoms of metabolic ... LacticAcidosis #Toxicity #Toxicology
Ethylene Glycol Toxicity

#Pathophysiology #Toxicology #EthyleneGlycol #Metabolism #Fomepizole
Glycol Toxicity #Pathophysiology ... #Toxicology #EthyleneGlycol ... #Metabolism #Fomepizole
Anion Gap Metabolic Acidosis
 • Diabetic Ketoacidosis ± Hyperglycemia ± Hyperosmolar
 • Alcoholic Ketoacidosis ± Hyperglycemia
Anion Gap Metabolic ... Acidosis • Diabetic ... Type B lactic acidosis ... - Drugs ( Albuterol ... 3rEtbK8 #AnionGap #Metabolic
High Anion Gap Metabolic Acidosis (HAGMA) - Mnemonics
Why should we switch from MUDPILES to GOLDMARK?
 •
High Anion Gap Metabolic ... Acidosis (HAGMA ... • Metabolic acidosis ... just two of many drugs ... #AnionGap #Metabolic
Toxic Alcohol Ingestion
Alcoholic ketoacidosis - Methanol - Ethylene glycol - Isopropyl Alcohol
 • Metabolic Acidosis
 •
Isopropyl Alcohol • Metabolic ... Acidosis • Osmolar ... Ingestion #diagnosis #toxicology
Causes of High-anion Gap and Non-anion Gap Metabolic Acidosis
Causes of High-anion Gap Acidosis:
 • Lactic acidosis
Non-anion Gap Metabolic ... Drugs II. ... Drug-induced hyperkalemia ... anti-inflammatory drugs ... aniongap #NonGap #Metabolic
Colchicine Toxicity 
Naturally-occurring plant alkaloid [Autumn Crocus and Glory Lilly]
2-24 hrs 
 • Severe GI distress
Renal failure • Metabolic ... acidosis • ARDS ... Colchicine #Toxicity #Toxicology
Salicylate Toxicity - Diagnosis and Management

Consider if:
1) Patient is hot and altered
2) You see tachypnea with
show anion-gap metabolic ... acidosis 4) Presentation ... Labs: Anion-Gap Metabolic ... Acidosis, Respiratory ... Aspirin #Toxicity #Toxicology
Refeeding Syndrome: Pathogenesis and clinical findings

Patients at Risk of Refeeding Syndrome:
 - Little or no nutritional
alcohol abuse or drugs ... • Incr Glucose Metabolism ... Syndrome - Metabolic ... Acidosis • Shift ... Syndrome #diagnosis #pathophysiology
Tramadol - Toxicology
Due to different CYP-2D6 genotypes, people variably metabolize tramadol into its active metabolite, M1
This
people variably metabolize ... into its active metabolite ... codeine ultra-rapid metabolism ... activity as the M1 metabolite ... in poor codeine metabolism