43 results
Ethylene Glycol Toxicity

#Pathophysiology #Toxicology #EthyleneGlycol #Metabolism #Fomepizole
Ethylene Glycol Toxicity ... #Pathophysiology ... EthyleneGlycol #Metabolism
Metformin Associated Lactic Acidosis (MALA) 

Pathophysiology of MALA
 - Metformin interferes with the activity of the
Acidosis (MALA) Pathophysiology ... use in cellular metabolism ... via anaerobic metabolism ... includes symptoms of metabolic ... LacticAcidosis #Toxicity
Colchicine Toxicity 
Naturally-occurring plant alkaloid [Autumn Crocus and Glory Lilly]
2-24 hrs 
 • Severe GI distress
Colchicine Toxicity ... Renal failure • Metabolic ... #Colchicine #Toxicity ... Toxicology #Symptoms #Signs
Acetaminophen metabolism and factors affecting toxicity. 
GSH = glutathione 

#Acetaminophen #APAP #metabolism #toxicity #Toxicology #Pathophysiology #Overdose
Acetaminophen metabolism ... factors affecting toxicity ... Acetaminophen #APAP #metabolism ... #toxicity #Toxicology ... #Pathophysiology
Salicylate Toxicity - Diagnosis and Management

Consider if:
1) Patient is hot and altered
2) You see tachypnea with
Salicylate Toxicity ... Diagnosis and Management ... show anion-gap metabolic ... Labs: Anion-Gap Metabolic ... Salicylate #Aspirin #Toxicity
Tramadol - Toxicology
Due to different CYP-2D6 genotypes, people variably metabolize tramadol into its active metabolite, M1
This
people variably metabolize ... into its active metabolite ... codeine ultra-rapid metabolism ... activity as the M1 metabolite ... in poor codeine metabolism
 Acute Iron Poisoning

There are five classically described phases of toxicity:
Gastrointestinal phase (~6 hours post-ingestion)
 -
described phases of toxicity ... absent in severe toxicity ... deterioration Shock and metabolic ... - Anion gap metabolic ... Toxicology #Diagnosis #Management
Refeeding Syndrome: Pathogenesis and clinical findings

Patients at Risk of Refeeding Syndrome:
 - Little or no nutritional
• Incr Glucose Metabolism ... Syndrome - Metabolic ... Syndrome #diagnosis #pathophysiology ... #symptoms #signs
Antifungal Azoles - Antibiotics Class Overview

Mechanism:  inhibit ergosterol synthesis (important component of fungal cell membranes)
membranes) - Main metabolism ... hepatic, main toxicity ... Isavuconazole(PO or IV) #Pharmacology
Propofol-Related Infusion Syndrome (PRIS)

Diagnosis is based on a constellation of clinical suspicion and biochemical signs including:
and biochemical signs ... Hyperlactatemia • Metabolic ... PRIS #Diagnosis #Management ... #Pharmacology # ... Toxicity #Toxicology