7 results
Metabolic Alkalosis - Urinary Chloride Algorithm
Cl- responsive metabolic alkalosis
 • Kidney loss of Cl-
loop or thiazide diuretics ... pressure: Active diuretic ... tubular acidosis ... tubular acidosis ... urine #Algorithm #nephrology
Hyperuricemia: Pathogenesis and Complications

 - Hypercalcemia (due to diseases like Sarcoidosis and Hyperparathyroidism) -> Accumulation of
decr ability of kidneys ... dose salicylates, diuretics ... in the nephron ... Hyperuricemia #Pathophysiology ... Complications #Gout
Gitelman Syndrome Pathophysiology
Gitelman Syndrome is a rare autosomal recessive salt-losing tubulopathy with a prevalence of 1-
thiazide-sensitive sodium-chloride ... in the distal tubule ... delivery to distal nephron ... → Hypokalemia Metabolic ... #nephrology #diagnosis
Hypochloremia - Differential Diagnosis Algorithm

Cause - Decreased Intake:
 • Low salt in diet
 • Exclusive D5W
RENAL LOSS: - Diuresis ... unloading • Kidney ... filtration rate by tubulo-glomerular ... Diagnosis #Algorithm #Pathophysiology ... #Nephrology #Chloride
Uric Acid Homeostasis
In the liver, purines are metabolized to uric acid. The last step in purine
step in purine metabolism ... produced The kidneys ... in the proximal tubule ... #Pathophysiology ... #Pharmacology #
Causes of High-anion Gap and Non-anion Gap Metabolic Acidosis
Causes of High-anion Gap Acidosis:
 • Lactic acidosis
Generalized distal nephron ... Chronic progressive kidney ... Potassium-sparing diuretics ... loads (ammonium chloride ... diagnosis #causes #nephrology
Gitelman Syndrome Overview

What?
• Inherited (AR) hypokalemic salt-losing tubulopathies affecting the thiazide-sensitive sodium chloride cotransporter
• Gitelman's syndrome
distal convoluted tubule ... with thiazide diuretic ... Surreptitious diuretic ... Syndrome #diagnosis #nephrology ... #management #pathophysiology