84 results
Gitelman Syndrome Overview

What?
• Inherited (AR) hypokalemic salt-losing tubulopathies affecting the thiazide-sensitive sodium chloride cotransporter
• Gitelman's syndrome
alkalosis • Normal ... Hypochloremic metabolic ... ratio 0.5%) Differential ... #diagnosis #nephrology ... #management #pathophysiology
Acid-Base Disorders - Differential Diagnosis Framework

 • Respiratory Acidosis
 • Respiratory Alkalosis
 • Metabolic Acidosis
 •
Acid-Base Disorders - Differential ... • Respiratory Alkalosis ... • Metabolic Alkalosis ... Base #Disorders #nephrology ... #differential #
Primary Metabolic Alkalosis - Differential Diagnosis Algorithm
Volume Depleted 2° hyperaldosteronism
 • Low Urine Cl-: Vomiting, NGT
Primary Metabolic ... Alkalosis - Differential ... #Primary #Metabolic ... #Alkalosis #Differential ... Diagnosis #Algorithm #nephrology
Primary Metabolic Alkalosis - Differential Diagnosis Algorithm
Volume Depleted - 2° hyperaldosteronism
 • Low Urine Cl-: Vomiting,
Primary Metabolic ... Alkalosis - Differential ... aldosteronism #Metabolic ... #Alkalosis #Differential ... Diagnosis #Algorithm #Nephrology
Hypokalemia - Differential Diagnosis Algorithm
Extra-renal Losses:
 • Normal Acid-Base: Low intake
 • Metabolic acidosis: Gl tract
Hypokalemia - Differential ... Low intake • Metabolic ... Renal Losses: • Metabolic ... Algorithm #causes #potassium ... #low #nephrology
Metabolic Alkalosis - Urinary Chloride Algorithm
Cl- responsive metabolic alkalosis
 • Kidney loss of Cl-
Metabolic Alkalosis ... of sodium and potassium ... #Metabolic #Alkalosis ... urine #Algorithm #nephrology ... #differential #
Hypokalemia Evaluation Algorithm

Before evaluating hypokalemia, life threatening complications such as arrhythmias and paralysis should be looked
treated with IV potassium ... Pressure: - Metabolic ... Alkalosis: Emesis ... diagnosis #Algorithm #differential ... #potassium #nephrology
Causes of Metabolic Alkalosis: Differential Diagnosis
ECF volume contracted: urine chloride concentration <20 meq/L
 • Gastric alkalosis:
Causes of Metabolic ... Alkalosis: Differential ... • Severe potassium ... #Alkalosis #Differential ... Diagnosis #Causes #nephrology
Hypokalemia - Differential Diagnosis Algorithm

Transcellular Shift:
 • Alkalosis
 • ↑ beta-2 adrenergic simulation 
 • Erythropoiesis
Hypokalemia - Differential ... Transcellular Shift: • Alkalosis ... • Refeeding syndrome ... Diagnosis #Algorithm #nephrology ... #low #potassium
Metabolic Alkalosis - Differential Diagnosis Algorithm - Urinary Chloride
 • Cl- responsive metabolic alkalosis
Metabolic Alkalosis ... - Differential ... diuretic use, Bartter syndrome ... , Gitelman syndrome ... #Alkalosis #Differential