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diagnosis differential druginduced algorithm alp injury phosphatase aflp arterial biliary cholangitis cirrhosis elevation embolism fatty function hyophosphatasia interpretation laboratory lfts
Drugs and Classes Associated with DILI and Type of Liver Injury #Medications #Differential #DrugInduced #LiverInjury #Hepatology #Pharmacology
Drugs and Classes ... and Type of Liver ... #LiverInjury #Hepatology ... #Pharmacology # ... Causes #DILI
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 Drug-Induced Liver Injury - Pathophysiology Indirect Idiosyncratic Direct BWH Medicine Chiefs @BrighamChiefs #DILI #DrugInduced #Liver #Injury #Pathophysiology #hepatology
Drug-Induced Liver ... Injury - Pathophysiology ... BrighamChiefs #DILI ... #DrugInduced #Liver ... #hepatology
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
Drug Induced Liver ... exposure to HDS, drugs ... non-essential drug ... for alternative causes ... Diagnosis #Algorithm #hepatology
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm ALP: - Enzymes that catalyze hydrolysis of organic phosphate
disturbance (obstructed liver ... Highest • Bone • Liver ... Intestine - Other causes ... Cholestasis - Drugs ... Diagnosis #Algorithm #hepatology
Liver Function Tests (LFTs) - Normal Values and Interpretation Alanine aminotransferase (ALT/SGPT) - Liver, cardiac & skeletal
Interpretation Alanine ... , lungs, RBCs Alkaline ... bilirubin (Conjugated/DBili ... impaired uptake (drugs ... Interpretation #diagnosis #hepatology
Acute Fatty Liver of Pregnancy (AFLP) Pathophysiology: • Defect in fetal free fatty acid metabolism products →
Pregnancy (AFLP) Pathophysiology ... = nonspecific (nausea ... 10x ULN), ↑Tbili/Dbili ... #Pregnancy #hepatology ... diagnosis #management #pathophysiology
Low Alkaline Phosphatase - Hypophosphatasia Is Low Alkaline Phosphatase Of Clinical Importance? ALP enzyme- Discovered in 1923 Low
synthesized in: liver ... Most cases diagnosed ... collection with EDTA Pathophysiology ... Phosphatase: • Other causes ... Hyophosphatasia #hepatology
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
65 years PBC Pathophysiology ... intralobular bile ducts causes ... PBC Labs: • Alkaline ... , Sarcoidosis, Drug-induced ... diagnosis #workup #hepatology
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework VENOUS THROMBOSIS • Acquired Risk Factors: - >48 hours
• Intravenous Drug ... Pregnancy • Drugs ... Syndrome, Ischemic Liver ... Venous #Arterial #pathophysiology ... #hematology #differential
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