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diagnosis management algorithm cardiology chemotherapy chronic cll cyp3a4 decisionaid differentiation doac dosing inducers inhibitors interactions leukemia lymphocytic mds medications myelodysplasia
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome in APML ... ATRA treatment Pathophysiology ... Differentiation #Syndrome #APML ... diagnosis #management #hematology ... #oncology
Managing warfarin INR Warfarin dosage must be individualized according to the patient's response to the drug, and
response to the drug ... management #algorithm #pharmacology ... #medications #table ... decisionaid #cardiology #hematology
(DOAC interactions) Cancer-treatment specific inducers (↑) and inhibitors (↓) of cytochrome p450 CYP3A4 and P-glycoprotein. DOACs are substrates
#Chemotherapy #Oncology ... #Hematology #Interactions ... #Table #Pharmacology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Transform to DLBCL, PML ... Leukemia #diagnosis #workup ... #oncology #hematology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
formed or don’t work ... Workup: • Complete ... progression to AML ... Syndromes #diagnosis #hematology ... #oncology
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