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diagnosis hematology algorithm anemia purpura workup bleeding classification extravascular hemolysis hodgkins intravascular leukemia lymphoma management mds myelodysplasia myelodysplastic nonpalpable palpable
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Extravascular Causes ... microangiopathy: Thrombotic thrombocytopenic ... Extravascular #Causes ... #differential # ... diagnosis #hematology
Causes of Bleeding / Bruising - Differential Diagnosis Algorithm Thrombocytopenia - Quantitative Defect • Decreased Production •
Causes of Bleeding ... / Bruising - Differential ... Diagnosis Algorithm Thrombocytopenia ... #Differential # ... #Hematology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
- Differential ... diverse genotypes): SS ... Schistocytes, thrombocytopenia ... #Anemia #Differential ... Algorithm #workup #hematology
Causes of Purpura or Easy Bruising in Children Platelet count reduced, i.e. thrombocytopenia - Increased platelet destruction
Causes of Purpura ... or Easy Bruising ... Non-immune - Haemolytic ... #Causes #peds # ... pediatrics #diagnosis #differential
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Purpura - Differential ... inflammation • Thrombocytopenia ... : - Thrombocytopenia ... DIC/TTP/HUS - Hemolytic ... #nonpalpable #dermatology
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
for Thrombotic Thrombocytopenic ... decrease in most cases ... WBC count and differential ... hematuria (without casts ... Diagnosis #Workup #Hematology
Causes of Petechial Rash - Differential Diagnosis Algorithm Pinpoint areas (less than 2 mm) of hemorrhage, which
Causes of Petechial ... Rash - Differential ... hemostasis: - Thrombocytopenia ... Diagnosis #Algorithm #Causes ... #dermatology #physicalexam
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
-> AML: Blast crises ... PLT: Petechiae, bruising ... infiltrates (anemia, thrombocytopenia ... #Leukemia #Hematology ... #Oncology #Diagnosis
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
hematological malignancy arising ... nodosum • Immune hemolytic ... Immunohistochemical studies (to differentiate ... classification #hematology ... #oncology #management
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
Easy or unusual bruising ... platelet count (thrombocytopenia ... IDUS) • Immune Thrombocytopenia ... blood count with differential ... #oncology
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