29 results
Myasthenia Gravis Overview

Myasthenia Gravis is an autoimmune disorder of the postsynaptic neuromuscular junction.  Ab to
Clinical Picture ... life-threatening Differential ... immunologic assay - MuSK ... Gravis #diagnosis #management ... #neurology
Causes of Neuromuscular Weakness
 • Spinal Cord: Demyelinating Disease (MS), Epidural abscess, Infarction, Syringomyelia, Tetanus, Transverse
Demyelinating Disease (MS ... Myelitis, Trauma, Tumor ... , Myasthenia Gravis ... #differential # ... diagnosis #neurology
Anticonvulsants as Mood Stabilizers: Mechanism and Side-effect
Examples: Valproate, Carbamazepine, Lamotrigine
 • Mild anticholinergic effect -> Drowsiness
Stevens-Johnson Syndrome ... Dose-dependent tremor ... • Neurologic ... Systemic effect -> Nausea ... pruritus, weight gain
Important Causes of Diplopia 
TIER 1-CRITICAL
Basilar artery thrombosis, Botulism, Basilar meningitis, Aneurysmn
TIER 2-EMERGENT:
Vertebral dissection, Myasthenia gravis,
Important Causes ... Diplopia TIER 1-CRITICAL ... Vertebral dissection, Myasthenia ... URGENT: Brainstem tumor ... mass #Diplopia #differential
Myasthenia Gravis - Summary
 • an autoimmune disease of the postsynaptic neuromuscular junction associated with antibodies
Diagnosis: • Based on clinical ... likely to cause ... for thymoma, a tumor ... Gravis #diagnosis #management ... #neurology #treatment
Diplopia - Double Vision - Differential Diagnosis Algorithm
Clinical Pearls:
 • Diplopia is almost always binocular.
 •
Double Vision - Differential ... Diagnosis Algorithm Clinical ... • Neurologic ... a mass as the cause ... • Myasthenia
Generalized Weakness - Differential Diagnosis Framework
"l feel weak":
 • Infectious: Influenza, EBV, PNA, Bacteremia, Sepsis
 •
Rhabdomyolysis, Critical ... : UMN (stroke, tumor ... NMJ disorder (Myasthenia ... #Diagnosis #causes ... #neurology
Ocular Myasthenia Gravis on Physical Exam

A 41yo female was referred by her neurologist for double vision.
Her clinical exam ... have a thymic tumor ... , and always ask ... #Gravis #PhysicalExam ... ophthalmology #neurology
Adie's Pupil
What? Unknown nature & benign
 • Regular and mildly dilated pupil (4-6mm);
 • Light-near dissociaton;
Holmes-Adie Syndrome ... Young females Differential ... dissociation • Other causes ... #Adies #Pupil #PhysicalExam ... #neurology #ophthalmology
Lesions of the Spinal cord - Spinal Cord Syndromes

Spinal cord lesions can result in permanent neurologic
result in permanent neurologic ... Causes of spinal ... • Extrinsic Causes ... #lesions #differential ... #diagnosis #neurology