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diagnosis differential management hematology algorithm clinical pathophysiology treatment thrombocytopenia pharmacology workup classification comparison criticalcare pediatrics table gastroenterology pulmonary nephrology peds
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
and Platelet Disorders ... History: - Prior platelet ... - History of bleeding ... epistaxis, gingival bleeding ... Thrombocytopenia #Platelet
Causes of Bleeding / Bruising - Differential Diagnosis Algorithm Thrombocytopenia - Quantitative Defect • Decreased Production •
Causes of Bleeding ... Sequestration Disordered Platelet ... Coagulation #Bleeding ... Diagnosis #Algorithm #Causes
Bleeding manifestations Petechiae are small, flat, red, discrete areas of skin bleeding that are typically <2
Bleeding manifestations ... areas of skin bleeding ... ecchymosis) is caused ... lowest levels Platelet ... ability to bind platelets
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
Findings: • Bleeding ... Findings in DIC: • Platelet ... Thrombocytopenia - Platelet ... Treat primary cause ... Coagulation #diagnosis #causes
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
to a low blood platelet ... neutrophils and platelets ... Neutropenia • Platelet ... blood cells or platelets ... blood cells or platelets
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
Bleeding and Bruising ... Qualitative defect in platelets ... characteristic of a platelet ... • Bleeding gums ... discern these causes
Blood Product Transfusions One Pager Summary Type and screen - determines blood type and detects in recipient
donor (apheresis) platelets ... transfusion, due to anti-platelet ... Causes purpura & ... common following platelet ... contamination: Platelets
Blood Transfusion Reactions Immune Mediated: • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
transfusion, due to anti-platelet ... Causes purpura & ... common following platelet ... coagulopathy & ↑bleeding ... contamination: Platelets
Idiopathic Thrombocytopenic Purpura Clinical: • Gingival • Menorrhagia • GI bleeding • Intracranial
Menorrhagia • GI bleeding ... children) • Platelets ... only for severe bleeding ... extremely low platelet
Inherited Qualitative Platelet Defects Bernard-Soulier Syndrome • Defect of adhesion due to a lack of GP Ib/IX/V
Inherited Qualitative Platelet ... Single isolated platelets ... without platelet ... failure Grey Platelet ... • Absence of platelet
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