29 results
ILD of Known Cause - Differential Diagnosis
Exposure:
 • Occupational: Asbestosis, Silicosis, Hypersensitivity, Pneumonitis
 • Treatment Related:
ILD of Known Cause ... Hypersensitivity, Pneumonitis ... • Treatment Related ... Polymyositis, Dermatomyositis ... BrighamChiefs #ILD
Autoimmune Myositis
Necrotizing myopathy is associated with higher CK levels, greater level of muscle weakness, less systemic
Dermatomyositis ... Classic triad of ILD ... after 2 years of treatment ... Myositis #diagnosis #rheumatology
ANTI-MDA5 DERMATOMYOSITIS

Cutaneous manifestations:
• Periorbital heliotrope (blue-purple) rash with edema
• Erythematous rash on the face, or the
the disease and ILD ... increases and ILD ... prevalence of RP-ILD ... Phenotype 1 ... #rheumatology #
Dermatomyositis (DM) and Polymyositis (PM): Pathogenesis and clinical findings
Elevated Antinuclear Antibodies: Anti-Jo-1, Anti-OJ, Anti-Mi2, Anti-SRP, Anti-EJ,
Dermatomyositis ... Antibodies: Anti-Jo-1, ... Demographics: - F:M, 2:1 ... dehydrogenase (LD ... PM #Diagnosis #Pathophysiology
Rhabdomyolysis - Differential Diagnosis and Management Summary

Trauma:
 • Immobilization, Crush iniury, Compartment syndrome, Electrical injury
Exertional:
 •
(polymyositis/Dermatomyositis ... ) AKI - Pathophysiology ... : 1. ... oxidative iniury Treatment ... Summary #causes #treatment
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Lymphohistiocytosis (HLH) Pathophysiology ... cytokines (TNFa,lL1, IL6 ... Unknown cause Treatment ... diagnosis #management #treatment ... #summary #rheumatology
Drug Induced Lupus vs SLE
Drug Induced Lupus (DIL):
 • Epidemiology: -10% of all lupus cases, drug-dependent,
to 1:1 F:M • Clinical ... Prognosis: Usually mild ... constitutional symptoms • Treatment ... life-threatening • Treatment ... comparison #table #rheumatology
Lung Abscess - Diagnosis and Management Summary

Lung Abscess Etiology:
 • Necrosis of lung parenchyma by a
Lung Abscess Pathophysiology ... : 1. ... Pneumonitis 3. ... hemorrhage • Treatment ... several months of treatment
Adult Onset Still's Disease
Systemic inflammation with urticarial rash.
Rash: 
 • Nonpruritic, evanescent (correlates with time of
should be major: 1. ... Treatment - Mild ... : NSAIDS Treatment ... anti-lL6R, anti-ILI ... AOSD #diagnosis #rheumatology
Guillain-Barre Syndrome - Summary

Acute AIDP that presents with rapidly progressive flaccid weakness

Epidemiology:
 • 1-2 cases/100,000 per
Epidemiology: • 1- ... Guillain-Barre Pathophysiology ... • Weakness: mild ... main variants: (1) ... Treatment: • Plasmapheresis