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diagnosis causes interstitial pulmonary diseases erythematosus lupus management sle systemic activation algorithm autoimmune complexes disease druginduced drugs hematology macrophage mas
Interstitial Lung Diseases (ILD) Exposure-Related ILD (a.k.a. extrinsic allergic alveolitis): • Hypersensitivity pneumonitis, Farmer's lung, Bird
Hypersensitivity pneumonitis ... • Radiation pneumonitis ... • Medication-induced ... ILD: Amiodarone ... #diagnosis #differential
ILD of Known Cause - Differential Diagnosis Exposure: • Occupational: Asbestosis, Silicosis, Hypersensitivity, Pneumonitis • Treatment Related:
- Differential ... Hypersensitivity, Pneumonitis ... • Treatment Related ... Methotrexate, Amiodarone ... #interstitial #lung
Amiodarone Induced Lung Toxicity Summary Who? • 5% of patients • Dose ≥ 400 mg per day How? Possible
Amiodarone Induced ... including: 1. ... Exclusion of other ILDs ... diagnostic of amiodarone-induced ... #Induced #Lung #
Causes of Interstitial Lung Disease - Differential Diagnosis Algorithm Idiopathic Interstitial Pneumonia • (UIP) Usual Interstitial Pneumonia
Disease - Differential ... this should be 1° ... Radiaition • Drugs: Amiodarone ... Chronic Radiation Pneumonitis ... #Diseases #ILD
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
-1 and IL-6, leading ... rash) • Heart, lung ... Sepsis • Drug-induced ... Treatment: • Corticosteroids ... #Rheumatology
Drug Induced Systemic Lupus Erythematosus > 100 drugs have been associated with drug-induced SLE High risk (>5%): •
Drug Induced Systemic ... year of treatment ... , Propafenone, Amiodarone ... pharmacology #risk #differential ... #diagnosis #rheumatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
permanent alopecia Differential ... Non-autoimmune rheumatologic ... • Acute lupus pneumonitis ... • ANA titers > 1: ... Ro/La, anti-Jo-1,
Premature Ventricular Complexes (PVC's) - Summary Framework Why PVCs? Can be the first manifestation of cardiac
., long QT syndrome ... Intermediate burden: >1 ... Cardiomyopathy (PVC-induced ... more intensive treatment ... #cardiology
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
Autoimmune Myositis - Differential ... thyroid, drug-induced ... Anti-MDA5 (RP-ILD ... Ab • Anti-Jo-1 ... #differential #
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