10 results
Antinuclear Antibody Testing - Nuclear and Cytoplasmic Patterns
Nuclear Patterns:
 • Homogeneous pattern: 
   -
Antinuclear Antibody ... SLE, SjS, CTD-ILD ... phenomenon - EJ, Jo-1, ... #differential # ... diagnosis #rheumatology
On the left some diseases with a nodular pattern.
1. Hypersensitivity pneumonitis: ill defined centrilobular nodules.
2. Miliary
with a nodular pattern ... . 1. ... Hypersensitivity pneumonitis ... Hypersensitivity pneumonitis ... NodularPattern #Differential
Skin Conditions Associated with Joint Pain

Rash
	• Human parvovirus B19 infection

Malar rash
	• SLE
	• Human parvovirus B19 infection
	•
gangrenosum • IBD ... Antiphospholipid-antibody ... Sarcoidosis #dermatology ... #skin #rashes #differential ... #diagnosis #rheumatology
Platelet disorders and Aggregometry
Glanzmann Thrombasthenia
 • Defective aggregation to all agonists except ristocetin
 • Normal platelet,
similar aggregation pattern ... cytometry — GP Ilb ... agonists • This pattern ... either severe Type 1 ... Platelet #disorders #hematology
Antinuclear Antibody Testing Cytoplasmic Patterns
Reticular/AMA: 
 • PBC, SSc, PBC/SSc OS, PBC/SjS OS
 • AMA
Speckled:
 •
Antinuclear Antibody ... SLE, SjS, CTD-ILD ... phenomenon • EJ, Jo-1, ... #differential # ... diagnosis #rheumatology
Causes of Abnormal PT and/or aPTT
Prolonged Prothrombin Time (PT)
1. Acquired deficiency of FVII
Prothrombin Time (PT) 1. ... FVIII antibody ... Prolonged PT and aPTT 1. ... Causes #diagnosis #differential ... #hematology #coagulation
Approach to Joint Pain - Arthritis Differential Diagnosis Framework

Inflammatory Versus Noninflammatory Pain
 • Is it inflammatory
Pain - Arthritis Differential ... • Is there a pattern ... lasting > 30 mins - 1 ... an asymmetric pattern ... #Joint #pain #Differential
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
permanent alopecia Differential ... Non-autoimmune rheumatologic ... • Acute lupus pneumonitis ... • ANA titers > 1: ... Ro/La, anti-Jo-1,
Anti-NXP-2 Dermatomyositis

What?
DM with generalized subcutaneous edema
Pts have more myalgias, more severe weakness, and an increased prevalence
levels • NXP-2 antibody ... Dermatomyositis: • ILD ... Prednisone at 1 ... diagnosis #management #rheumatology ... #dermatology
Autoimmune Myositis - Differential Diagnosis Framework

Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
Autoimmune Myositis - Differential ... Anti-MDA5 (RP-ILD ... Ab • Anti-Jo-1 ... slow onset and pattern ... #differential #