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diagnosis ana antinuclear cytoplasmic hematology patterns testing abnormal aggregometry antinxp2 antinxp2dm aptt causes coagulation dermatomyositis disorders erythematosus hemepath joint lupus
Skin Conditions Associated with Joint Pain Rash • Human parvovirus B19 infection Malar rash • SLE • Human parvovirus B19 infection •
gangrenosum • IBD ... Antiphospholipid-antibody ... Sarcoidosis #dermatology ... #skin #rashes #differential ... #diagnosis #rheumatology
Antinuclear Antibody Testing - Nuclear and Cytoplasmic Patterns Nuclear Patterns: • Homogeneous pattern: -
Antinuclear Antibody ... SLE, SjS, CTD-ILD ... phenomenon - EJ, Jo-1, ... Cytoplasmic #Patterns #differential ... #diagnosis #rheumatology
Platelet disorders and Aggregometry Glanzmann Thrombasthenia • Defective aggregation to all agonists except ristocetin • Normal platelet,
cytometry — GP Ilb ... either severe Type 1 ... or Type 3) — differentiate ... Platelet #disorders #hematology ... #hemepath #differential
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Prothrombin Time (PT) 1. ... FVIII antibody ... Prolonged PT and aPTT 1. ... Causes #diagnosis #differential ... #hematology #coagulation
Antinuclear Antibody Testing Cytoplasmic Patterns Reticular/AMA: • PBC, SSc, PBC/SSc OS, PBC/SjS OS • AMA Speckled: •
Antinuclear Antibody ... SLE, SjS, CTD-ILD ... phenomenon • EJ, Jo-1, ... Cytoplasmic #Patterns #differential ... #diagnosis #rheumatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
permanent alopecia Differential ... Non-autoimmune rheumatologic ... • Acute lupus pneumonitis ... • ANA titers > 1: ... Ro/La, anti-Jo-1,
Anti-NXP-2 Dermatomyositis What? DM with generalized subcutaneous edema Pts have more myalgias, more severe weakness, and an increased prevalence
levels • NXP-2 antibody ... Dermatomyositis: • ILD ... Prednisone at 1 ... diagnosis #management #rheumatology ... #dermatology
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