9 results
Antinuclear Antibody Testing - Nuclear and Cytoplasmic Patterns
Nuclear Patterns:
 • Homogeneous pattern: 
   -
Antinuclear Antibody ... Testing - Nuclear ... SLE, SjS, CTD-ILD ... phenomenon - EJ, Jo-1, ... differential #diagnosis #rheumatology
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases

• Septic arthritis - Gram stain and culture of
Rheumatology Workup ... Studies in Rheumatic Diseases ... CRP level: (1) ... as opposed to 1 ... #Rheumatology
Antinuclear Antibody Testing Cytoplasmic Patterns
Reticular/AMA: 
 • PBC, SSc, PBC/SSc OS, PBC/SjS OS
 • AMA
Speckled:
 •
Antinuclear Antibody ... Testing Cytoplasmic ... SLE, SjS, CTD-ILD ... phenomenon • EJ, Jo-1, ... differential #diagnosis #rheumatology
Adult Onset Still's Disease
Systemic inflammation with urticarial rash.
Rash: 
 • Nonpruritic, evanescent (correlates with time of
Onset Still's Disease ... should be major: 1. ... Treatment - Mild ... onset #Stills #disease ... AOSD #diagnosis #rheumatology
Platelet disorders and Aggregometry
Glanzmann Thrombasthenia
 • Defective aggregation to all agonists except ristocetin
 • Normal platelet,
cytometry — GP Ilb ... either severe Type 1 ... Von Willebrand Disease ... considered first-line testing ... Platelet #disorders #hematology
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Non-autoimmune rheumatologic ... • Acute lupus pneumonitis ... CNS • Headache, mild ... • ANA titers > 1: ... Ro/La, anti-Jo-1,
Approach to Joint Pain - Arthritis Differential Diagnosis Framework

Inflammatory Versus Noninflammatory Pain
 • Is it inflammatory
Morning stiffness lasting ... > 30 mins - 1 hour ... - Autoimmune Rheumatologic ... Ankylosing Spondylitis, IBD ... Diagnosis #MSK #rheumatology
CPPD vs Gout

== CPPD == 

Think About CPPD When:
 • Self-limited synovitis after surgery/trauma (> 65
trauma (> 65 years old ... • Underlying disease ... to Manifest: 1. ... Synovial Fluid Testing ... Gout #Comparison #rheumatology
Anti-NXP-2 Dermatomyositis

What?
DM with generalized subcutaneous edema
Pts have more myalgias, more severe weakness, and an increased prevalence
levels • NXP-2 antibody ... had more severe disease ... Prednisone at 1 ... methylprednisolone 1 ... diagnosis #management #rheumatology