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diagnosis treatment lupus syndrome bleeding differential druginduced hemeonc hemophagocytic hlh lymphohistiocytosis mds myelodysplastic sle algorithm arthritis blood bruising classification comparison
Algorithm for the Evaluation and Management of Sickle Cell Crises Clinical Manifestations and Management #Diagnosis #Management #Hematology #SickleCell
Algorithm for the Evaluation ... and Management ... of Sickle Cell Crises ... #Hematology #SickleCell ... Manifestations #Workup
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Summary • Epidemiology ... of SLE versus DIL ... • Immunologic Workup ... of SLE • Evolution ... #Summary #rheumatology
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Summary myelo ... diagnosis: 70 years old ... , ~10,000 new cases ... #treatment #hematology ... #oncology
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
• Immunologic Workup ... Prognosis: Usually mild ... Discontinuation of causal ... • Immunologic Workup ... comparison #table #rheumatology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Drugs, Unknown cause ... inhibitors under evaluation ... Lymphohistiocytosis #diagnosis #management ... #treatment #summary ... #rheumatology
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
TTP - Laboratory Evaluation ... decrease in most cases ... hematuria (without casts ... ThromboticThrombocytopenicPurpura #Diagnosis #Workup ... #Hematology
Drug Induced Lupus (DIL) • Epidemiology: -10% of all lupus cases, drug-dependent, 4:1 to 1:1 F:M
• Immunologic Workup ... Prognosis: Usually mild ... • Evolution: ... #rheumatology # ... diagnosis #treatment #management
SAPHO Syndrome Summary What? SAPHO syndrome is a rare chronic inflammatory disorder of bone, joint, and skin characterized
SAPHO Syndrome Summary ... efficacious include IL ... -1 inhibitors, IL ... inhibitors, and IL ... SAPHO #Syndrome #Rheumatology
Rheumatoid Arthritis Summary Overview: chronic, inflammatory symmetric polyarthritis involving small joints of hands/feet, knees, shoulders Signs & Symptoms:
Rheumatoid Arthritis Summary ... Certolizumab, Golimumab), IL ... Arthritis #diagnosis #management ... #rheumatology
Monoclonal Gammopathy of Undetermined Significance (MGUS) - Summary Framework Hematologic disorder characterized by the presence of either
Significance (MGUS) - Summary ... Framework Hematologic ... isotype (rarely IgD ... #Significance #hematology ... #diagnosis #oncology
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