21 results
Glomerular Tuft on Electron Microscopy

This eyeSCANdy image shows acellular scanning EM of a normal glomerular tuft
Glomerular Tuft ... acellular scanning EM ... normal glomerular tuft ... removal of the podocytes ... ElectronMicroscopy #SEM
Glomerular Tuft on Electron Microscopy

This eyeSCANdy image shows acellular scanning EM of a normal glomerular tuft
Glomerular Tuft ... acellular scanning EM ... normal glomerular tuft ... removal of the podocytes ... ElectronMicroscopy #SEM
This image shows glomerular tuft with overall intact architecture. Discrete masses of specular amyloid interrupt smooth
shows glomerular tuft ... #desposition #deposits ... ElectronMicroscopy #SEM
This image shows portions of glomerular tuft with collapsed GBM (across top), spicular amyloid (middle right),
of glomerular tuft ... #desposition #deposits ... ElectronMicroscopy #SEM
This image shows a glomerular tuft with overall intact architecture. Discrete masses of specular amyloid (long
shows a glomerular tuft ... #desposition #deposits ... ElectronMicroscopy #SEM
This image shows acellular scanning EM with normal glomerular tuft at top and segmental necrosis at
acellular scanning EM ... normal glomerular tuft ... necrosis #glomerular #tuft ... ElectronMicroscopy #SEM
Membranoproliferative Glomerulonephritis (MPGN) AKA: Mesangiocapillary GN
 • Active Urine Sediment (dysmorphic RBC, RBC casts, +/- proteinuria)
glomerulopathy (Dense deposit ... Minimal immune deposits ... on EM, negative
Rapidly Progressive Glomerulonephritis (RPGN) 
 - Loss of kidney function over a short period of tirne
Presence of immune deposits ... staining on IF • No EM ... deposits Pauci-lmmune ... Minimal immune deposits
Podocytopathies - Differential Diagnosis Algorithm

No podocytopenia - EM shows minimal change disease
 • Minimal Change Nephropathy
Podocytopenia
podocytopenia - EM ... • FSGS NOS Podocyte ... Podocytopathy #podocytes
Pathogenesis of PLA2R-associated (primary) Membranous Nephropathy

Immune deposits  → Activate complement  → C5b-9 complex
Nephropathy Immune deposits ... C5b-9 complex → Podocyte