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diagnosis hematology coagulation anticoagulation ptt abnormal causes differential doac heparin laboratory prolonged testing thrombin warfarin anticoagulants apaxiban apixaban bleeding bruising
How to Evaluate an Abnormal APTT Step 1: Is the PT or APTT Artifactually Prolonged? Step 2: Is
Step 1: Is the PT ... Patient Receiving Anticoagulants ... Heparin, or Direct Thrombin ... Prolonging the PT ... or APTT?
Effect of Anticoagulants on Coagulation Tests PT / INR, aPTT, Anti-Xa Activity, Activated Clotting Time, Thrombin Time,
Effect of Anticoagulants ... Coagulation Tests PT ... / INR, aPTT, Anti-Xa ... Clotting Time, Thrombin ... EricsMedicalLectures/ #Anticoagulants
Coagulation cascade and anticoagulants Satyendra Dhar MD, @DharSaty #coagulation #coumadin #heparin #warfarin #apaxiban #pradaxa #xarelto #DOAC #vWF
Coagulation cascade and anticoagulants ... xarelto #DOAC #vWF #thrombin ... #ptt #pt
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Causes of Abnormal PT ... Prothrombin Time (PT ... heparin - Other anticoagulants ... typically prolong PT ... drugs e.g. direct thrombin
The coagulation cascade is shown, separated into different phases with their endogenous and pharmacological inhibitors shown.
at the site of injury ... FVa to generate thrombin ... Thrombin, then primes ... #clot #PT #PTT ... anticoagulation #anticoagulant
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
inhibitor and lupus anticoagulant ... syndrome • Lupus anticoagulant ... deficiency • Anticoagulants ... warfarin, direct thrombin ... deficiency • Anticoagulant
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
• Prolonged PT ... • Increased thrombin ... Fibrinogen: ↓ • PT ... Reduction of pro/anticoagulants ... INR < 2.3 - APTT
Effect of Direct Oral Anticoagulants on Hemostatic Tests Horizontal bars correspond to the approximate range of detectability
of Direct Oral Anticoagulants ... within and above typical ... clotting time; TT = thrombin ... laboratory #testing #aptt
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