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diagnosis aptt coagulation differential abnormal anticoagulation causes prolonged ptt apixaban bleeding bruising cascade chemistry clot dabigatran dic disseminated doac edoxaban
How to Evaluate an Abnormal APTT Step 1: Is the PT or APTT Artifactually Prolonged? Step 2: Is
Step 1: Is the PT ... Patient Receiving Anticoagulants ... Heparin, or Direct Thrombin ... Prolonging the PT ... prolonged #diagnosis #hematology
The coagulation cascade is shown, separated into different phases with their endogenous and pharmacological inhibitors shown.
at the site of injury ... Thrombin, then primes ... #clot #PT #PTT ... diagnosis #models #hematology ... anticoagulation #anticoagulant
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
syndrome • Lupus anticoagulant ... deficiency • Anticoagulants ... warfarin, direct thrombin ... deficiency • Anticoagulant ... Differential #Diagnosis #Hematology
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Causes of Abnormal PT ... Prothrombin Time (PT ... heparin - Other anticoagulants ... drugs e.g. direct thrombin ... #differential #hematology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
ALF): • Liver injury ... AST/ALT > ALP: Typical ... ALP > AST/ALT: typical ... Coagulation factors: PT ... #differential #Hepatology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
• Prolonged PT ... • Increased thrombin ... Fibrinogen: ↓ • PT ... Reduction of pro/anticoagulants ... treatment #management #hematology
Effect of Direct Oral Anticoagulants on Hemostatic Tests Horizontal bars correspond to the approximate range of detectability
of Direct Oral Anticoagulants ... within and above typical ... clotting time; TT = thrombin ... anticoagulation #hematology
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