9 results
Coagulation cascade and anticoagulants 

Satyendra Dhar MD, @DharSaty

#coagulation #coumadin #heparin #warfarin #apaxiban #pradaxa #xarelto #DOAC #vWF
Coagulation cascade and anticoagulants ... coagulation #coumadin #heparin ... #warfarin #apaxiban ... xarelto #DOAC #vWF #thrombin ... #ptt #pt
Effect of Anticoagulants on Coagulation Tests
PT / INR, aPTT, Anti-Xa Activity, Activated Clotting Time, Thrombin Time,
Effect of Anticoagulants ... Coagulation Tests PT ... Clotting Time, Thrombin ... Rivaroxaban Apixaban ... EricsMedicalLectures/ #Anticoagulants
How to Evaluate an Abnormal APTT
Step 1: Is the PT or APTT Artifactually Prolonged?
Step 2: Is
to Evaluate an Abnormal ... Step 1: Is the PT ... Patient Receiving Anticoagulants ... K Antagonists, Heparin ... , or Direct Thrombin
The coagulation cascade is shown, separated into different phases with their endogenous and pharmacological inhibitors shown.
at the site of injury ... #clot #PT #PTT ... anticoagulation #anticoagulant ... #inhibitor #Apixaban ... Rivaroxaban #Edoxaban #heparin
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework

== Quantitative or Qualitative defect in
PT/ABNORMAL PTT ... inhibitor and lupus anticoagulant ... syndrome • Lupus anticoagulant ... deficiency • Anticoagulants ... deficiency • Anticoagulant
Causes of Abnormal PT and/or aPTT
Prolonged Prothrombin Time (PT)
1. Acquired deficiency of FVII
Causes of Abnormal ... - Rivaroxaban, apixaban ... - Other anticoagulants ... drugs e.g. direct thrombin ... Jcortesizaguirr #Abnormal
Effect of Direct Oral Anticoagulants on Hemostatic Tests
Horizontal bars correspond to the approximate range of detectability
of Direct Oral Anticoagulants ... within and above typical ... , rixaroxaban, apixaban ... assay; ECT = ecarin ... clotting time; TT = thrombin
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
• Prolonged PT ... • Increased thrombin ... Fibrinogen: ↓ • PT ... Reduction of pro/anticoagulants ... 100mg/dL) - Heparin
Liver Chemistries - Interpretation of LFTs

R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP)
 • R >
AST/ALT > ALP: Typical ... - If both are normal ... Coagulation factors: PT ... replaced by non-hepatic ... Hemolysis #liver #chemistry