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coagulation diagnosis causes abnormal anticoagulant anticoagulation aptt cascade clinical clots dabigatran dic differential disseminated echocardiogram heparin inhibitor intransit intravascular management
The coagulation cascade is shown, separated into different phases with their endogenous and pharmacological inhibitors shown.
FVa to generate thrombin ... Thrombin, then primes ... large amounts of thrombin ... Cascade #platelet #thrombin ... #clot #PT #PTT
This 24M presented with acute onset CP/SOB, hypoxia, HR 150s. What's the diagnosis? Treatment options? Hint:
Thrombus in transit ... Pt had extensive ... Echocardiogram #A4C ... PulmonaryEmbolism #Thrombus ... #Clots #InTransit
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 Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Causes of Abnormal PT ... - Rivaroxaban, apixaban ... , edoxaban (typically ... drugs e.g. direct thrombin ... #differential #hematology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
• Prolonged PT ... • Increased thrombin ... Fibrinogen: ↓ • PT ... significant fibrin clot ... treatment #management #hematology
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