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coagulation diagnosis causes intravascular abnormal anticoagulant anticoagulation apixaban aptt cascade dabigatran differential heparin inhibitor isth laboratory management models pathophysiology pathway
ISTH Scoring System for Disseminated Intravascular Coagulation (DIC) Platelet count: • Expected: Low (or normal) • Elevation
Scoring System for Disseminated ... using INR use PT ... to form clots, ... #Disseminated # ... Scoring #diagnosis #hematology
The coagulation cascade is shown, separated into different phases with their endogenous and pharmacological inhibitors shown.
Thrombin, then primes ... and endothelial cells ... #clot #PT #PTT ... diagnosis #models #hematology ... #Rivaroxaban #Edoxaban
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
Disseminated Intravascular ... • Prolonged PT ... • Increased thrombin ... significant fibrin clot ... treatment #management #hematology
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Rivaroxaban, apixaban, edoxaban ... drugs e.g. direct thrombin ... Disseminated intravascular ... coagulation (DIC ... #differential #hematology
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