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diagnosis hematology differential abnormal aptt cardiology clinical echocardiogram pocus prolonged anticoagulant anticoagulation apixaban blanching bleeding bruise bruising cardiac cascade clot
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Causes of Abnormal ... Pre-analytical cause ... drugs e.g. direct thrombin ... intravascular coagulation ... aPTT #Prolonged #Causes
The coagulation cascade is shown, separated into different phases with their endogenous and pharmacological inhibitors shown.
The coagulation ... Thrombin, then primes ... and endothelial cells ... #Coagulation #Cascade ... #clot #PT #PTT
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
• Prolonged PT ... • Increased thrombin ... Fibrinogen: ↓ • PT ... Treat primary cause ... #diagnosis #causes
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
for a Prolonged PT ... and aPTT If the PT ... Causes include : ... drugs (e.g. direct thrombin ... differential #hematology #coagulation
Constrictive Pericarditis on POCUS Echocardiogram - Subcostal View Young Lupus patient admitted to hospital new onset HFpEF.
could pinpoint the cause ... Also has pericardial ... effusion/pericardial ... one month ago-pt ... clinical #cardiology #s4C
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 Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
inhibitor of a coagulation ... == NORMAL PT ... intravascular coagulation ... discern these causes ... warfarin, direct thrombin
Complex Pericardial Effusion with Tamponade on POCUS Echocardiogram - A4C Pt sent to ED c intradialytic hypotension.
Echocardiogram - A4C ... Pt sent to ED c ... Pt has large pericardial ... consider serious causes ... Echocardiogram #A4C
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 Bleeding manifestations Petechiae are small, flat, red, discrete areas of skin bleeding that are typically <2
ecchymosis) is caused ... are typical of coagulation ... in endothelial cells ... to be normal, PT ... Measurement of coagulation
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