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diagnosis hematology causes dic differential intravascular abnormal anticoagulation apixaban aptt bleeding bruising cascade dabigatran edoxaban hemostasis heparin inhibitor isth laboratory
ISTH Scoring System for Disseminated Intravascular Coagulation (DIC) Platelet count: • Expected: Low (or normal) • Elevation
Scoring System for Disseminated ... platelet aggregation PT ... using INR use PT ... to form clots, ... vessels #DIC #Disseminated
The coagulation cascade is shown, separated into different phases with their endogenous and pharmacological inhibitors shown.
The coagulation ... and endothelial cells ... #Coagulation #Cascade ... #clot #PT #PTT ... anticoagulation #anticoagulant
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
Disseminated Intravascular ... • Prolonged PT ... • Increased thrombin ... significant fibrin clot ... Reduction of pro/anticoagulants
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
heparin - Other anticoagulants ... Congenital intrinsic coagulation ... drugs e.g. direct thrombin ... Disseminated intravascular ... coagulation (DIC
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
inhibitor of a coagulation ... liver failure, disseminated ... intravascular coagulation ... warfarin, direct thrombin ... deficiency • Anticoagulant
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