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diagnosis hematology causes differential abnormal aptt dic intravascular algorithm anticoagulant anticoagulation apixaban bleeding bruising cascade dabigatran edoxaban hemorrhage hemostasis heparin
ISTH Scoring System for Disseminated Intravascular Coagulation (DIC) Platelet count: • Expected: Low (or normal) • Elevation
Scoring System for Disseminated ... platelet aggregation PT ... using INR use PT ... to form clots, ... vessels #DIC #Disseminated
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Congenital intrinsic coagulation ... drugs e.g. direct thrombin ... Disseminated intravascular ... coagulation (DIC ... differential #hematology #coagulation
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
Disseminated Intravascular ... Thrombocytopenia • Prolonged ... PT/PTT • Low ... • Increased thrombin ... significant fibrin clot
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
PT and aPTT If ... the PT and the ... drugs (e.g. direct thrombin ... hemorrhage • Disseminated ... differential #hematology #coagulation
The coagulation cascade is shown, separated into different phases with their endogenous and pharmacological inhibitors shown.
The coagulation ... Thrombin, then primes ... and endothelial cells ... #Coagulation #Cascade ... #clot #PT #PTT
Causes of Post-Partum Hemorrhage - Differential Diagnosis Algorithm Blood Loss: >500mL post vaginal delivery OR >1000 mL
fatigue (e.g. prolonged ... Retained blood clots ... or percreta) Thrombin ... HELLP syndrome • Disseminated ... intravascular coagulation
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
inhibitor of a coagulation ... prolonged after ... liver failure, disseminated ... intravascular coagulation ... warfarin, direct thrombin
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