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diagnosis hematology causes differential abnormal aptt intravascular prolonged anticoagulant anticoagulation bleeding bruising cascade clot dabigatran edoxaban hemostasis heparin inhibitor isth
ISTH Scoring System for Disseminated Intravascular Coagulation (DIC) Platelet count: • Expected: Low (or normal) • Elevation
Scoring System for Disseminated ... (DIC) Platelet ... platelet aggregation PT ... using INR use PT ... #Disseminated #
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
Disseminated Intravascular ... Coagulation (DIC ... • Prolonged PT ... • Increased thrombin ... #Disseminated #
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
- Rivaroxaban, apixaban ... Congenital intrinsic coagulation ... drugs e.g. direct thrombin ... Disseminated intravascular ... coagulation (DIC
The coagulation cascade is shown, separated into different phases with their endogenous and pharmacological inhibitors shown.
The coagulation ... and endothelial cells ... #Coagulation #Cascade ... #clot #PT #PTT ... #inhibitor #Apixaban
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
for a Prolonged PT ... drugs (e.g. direct thrombin ... hemorrhage • Disseminated ... intravascularcoagulation (DIC ... differential #hematology #coagulation
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
inhibitor of a coagulation ... Warfarin • Acute DIC ... liver failure, disseminated ... disease • Acute DIC ... warfarin, direct thrombin
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