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diagnosis hematology causes differential intravascular abnormal prolonged anticoagulant anticoagulation apixaban bleeding bruising cascade clot dabigatran edoxaban hemostasis heparin honc inhibitor
ISTH Scoring System for Disseminated Intravascular Coagulation (DIC) Platelet count: • Expected: Low (or normal) • Elevation
Scoring System for Disseminated ... (DIC) Platelet ... , aPTT: • Expected ... using INR use PT ... #Disseminated #
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
Disseminated Intravascular ... Coagulation (DIC ... • Prolonged PT ... • Increased thrombin ... #Disseminated #
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Congenital intrinsic coagulation ... drugs e.g. direct thrombin ... Disseminated intravascular ... coagulation (DIC ... differential #hematology #coagulation
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
PT and the aPTT ... drugs (e.g. direct thrombin ... hemorrhage • Disseminated ... intravascularcoagulation (DIC ... differential #hematology #coagulation
Therefore, studies obtained at the initial presentation in the emergency department should evaluate for fibrinolysis with
prothrombin time (PT ... thromboplastin time (PTT ... decompensated DIC ... LaboratoryFindings #Disseminated ... Intravascular #Coagulation
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
inhibitor of a coagulation ... Warfarin • Acute DIC ... failure, disseminated ... disease • Acute DIC ... warfarin, direct thrombin
The coagulation cascade is shown, separated into different phases with their endogenous and pharmacological inhibitors shown.
The coagulation ... Thrombin, then primes ... and endothelial cells ... #Coagulation #Cascade ... #clot #PT #PTT
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