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diagnosis hematology causes aptt dic intravascular prolonged algorithm blanching bleeding bruise bruising chemistry ecchymosis hematomas hemorrhage hemostasis hepatology interpretation isth
ISTH Scoring System for Disseminated Intravascular Coagulation (DIC) Platelet count: • Expected: Low (or normal) • Elevation
Scoring System for Disseminated ... Intravascular Coagulation ... platelet aggregation PT ... using INR use PT ... vessels #DIC #Disseminated
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
Disseminated Intravascular ... • Prolonged PT ... • Increased thrombin ... Fibrinogen: ↓ • PT ... Schistocytes, helmet cells
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Causes of Abnormal ... drugs e.g. direct thrombin ... Disseminated intravascular ... Jcortesizaguirr #Abnormal ... Causes #diagnosis #differential
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
Differential Diagnosis ... drugs (e.g. direct thrombin ... hemorrhage • Disseminated ... amyloidosis #Abnormal ... #hematology #coagulation
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
PT/NORMAL PTT: ... PT/ABNORMAL PTT ... PT/NORMAL PTT: ... PT/ABNORMAL PTT ... warfarin, direct thrombin
Causes of Post-Partum Hemorrhage - Differential Diagnosis Algorithm Blood Loss: >500mL post vaginal delivery OR >1000 mL
Post-Partum Hemorrhage - Differential ... succenturiate lobe • Abnormal ... or percreta) Thrombin ... HELLP syndrome • Disseminated ... intravascular coagulation
Bleeding manifestations Petechiae are small, flat, red, discrete areas of skin bleeding that are typically <2
are typical of coagulation ... in endothelial cells ... , PT should be normal ... Measurement of coagulation ... VWF:RCo/VWF:Ag (differentiate
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
- If both are normal ... • Albumin • Coagulation ... factors: PT/INR ... intestines, White blood cells ... chemistry #diagnosis #differential
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