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diagnosis hematology abnormal aptt prolonged algorithm blanching bleeding bruise dic ecchymosis emergencies hematomas hemeonc hemostasis intravascular management obgyn obstetrics oncologic
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
Differential Diagnosis ... drugs (e.g. direct thrombin ... • Massive hemorrhage ... • Disseminated ... #hematology #coagulation
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Causes of Abnormal ... drugs e.g. direct thrombin ... Massive hemorrhage ... Disseminated intravascular ... #diagnosis #differential
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
Disseminated Intravascular ... • Prolonged PT ... • Increased thrombin ... Acral cyanosis • Hemorrhagic ... Fibrinogen: ↓ • PT
Causes of Post-Partum Hemorrhage - Differential Diagnosis Algorithm Blood Loss: >500mL post vaginal delivery OR >1000 mL
Causes of Post-Partum ... Hemorrhage - Differential ... or percreta) Thrombin ... HELLP syndrome • Disseminated ... #PPH #Differential
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
Bleeding and Bruising ... of Hemostasis - Differential ... liver failure, disseminated ... discern these causes ... warfarin, direct thrombin
Bleeding manifestations Petechiae are small, flat, red, discrete areas of skin bleeding that are typically <2
ecchymosis) is caused ... in endothelial cells ... Excessive bruising ... to be normal, PT ... VWF:RCo/VWF:Ag (differentiate
Summary of Oncologic Emergencies Neutropenic fever: - Fever + ANC < 500 → start cefepime ± vancomycin (if
rising > 500 → ... first) DIC (disseminated ... intravascular coagulation ... Treat underlying cause ... “big & sticky” cells
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