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diagnosis hematology causes differential abnormal anticoagulation aptt dic intravascular laboratory prolonged anticoagulant anticoagulants apixaban bleeding bruising cascade clot dabigatran effects
ISTH Scoring System for Disseminated Intravascular Coagulation (DIC) Platelet count: • Expected: Low (or normal) • Elevation
Scoring System for Disseminated ... Intravascular Coagulation ... platelet aggregation PT ... using INR use PT ... vessels #DIC #Disseminated
Effect of Anticoagulants on Coagulation Tests PT / INR, aPTT, Anti-Xa Activity, Activated Clotting Time, Thrombin Time,
Anticoagulants on Coagulation ... Tests PT / INR, ... Clotting Time, Thrombin ... Rivaroxaban Apixaban, Edoxaban
The coagulation cascade is shown, separated into different phases with their endogenous and pharmacological inhibitors shown.
The coagulation ... and endothelial cells ... #Coagulation #Cascade ... #clot #PT #PTT ... #Rivaroxaban #Edoxaban
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Rivaroxaban, apixaban, edoxaban ... Congenital intrinsic coagulation ... drugs e.g. direct thrombin ... Disseminated intravascular ... coagulation (DIC
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
Disseminated Intravascular ... • Prolonged PT ... • Increased thrombin ... Fibrinogen: ↓ • PT ... Schistocytes, helmet cells
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
for a Prolonged PT ... and aPTT If the PT ... drugs (e.g. direct thrombin ... hemorrhage • Disseminated ... differential #hematology #coagulation
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
inhibitor of a coagulation ... == NORMAL PT ... liver failure, disseminated ... intravascular coagulation ... warfarin, direct thrombin
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