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hematology causes differential abnormal disseminated intravascular prolonged anticoagulant anticoagulation apixaban bleeding bruising cascade clot dabigatran edoxaban hemostasis heparin inhibitor isth
ISTH Scoring System for Disseminated Intravascular Coagulation (DIC) Platelet count: • Expected: Low (or normal) • Elevation
(DIC) Platelet ... platelet aggregation PT ... , aPTT: • Expected ... using INR use PT ... ISTH #Scoring #diagnosis
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Congenital intrinsic ... coagulation factors ... drugs e.g. direct thrombin ... (DIC) c. ... #Causes #diagnosis
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
PT and the aPTT ... affected in the intrinsic ... drugs (e.g. direct thrombin ... intravascularcoagulation (DIC ... differential #hematology #coagulation
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
• Prolonged PT ... • Increased thrombin ... Fibrinogen: ↓ • PT ... INR < 2.3 - APTT ... #diagnosis #causes
The coagulation cascade is shown, separated into different phases with their endogenous and pharmacological inhibitors shown.
The coagulation ... along with FXIIa (intrinsic ... #Coagulation #Cascade ... #clot #PT #PTT ... #diagnosis #models
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
- Differential Diagnosis ... inhibitor of a coagulation ... Warfarin • Acute DIC ... disease • Acute DIC ... warfarin, direct thrombin
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