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hematology coagulation causes differential abnormal disseminated prolonged bleeding bruising hemostasis isth laboratory management scoring treatment
ISTH Scoring System for Disseminated Intravascular Coagulation (DIC) Platelet count: • Expected: Low (or normal) • Elevation
for Disseminated Intravascular ... Coagulation (DIC ... , aPTT: • Expected ... using INR use PT ... ISTH #Scoring #diagnosis
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Congenital intrinsic ... drugs e.g. direct thrombin ... Disseminated intravascular ... coagulation (DIC ... #Causes #diagnosis
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
Disseminated Intravascular ... • Prolonged PT ... • Increased thrombin ... Fibrinogen: ↓ • PT ... #Coagulation #diagnosis
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
Differential Diagnosis ... PT and the aPTT ... affected in the intrinsic ... drugs (e.g. direct thrombin ... intravascularcoagulation (DIC
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
- Differential Diagnosis ... Warfarin • Acute DIC ... , disseminated intravascular ... disease • Acute DIC ... warfarin, direct thrombin
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