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hematology causes differential abnormal disseminated intravascular anticoagulant anticoagulation apixaban bleeding bruising cascade clot dabigatran edoxaban hemostasis heparin inhibitor isth laboratory
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
and/or aPTT Prolonged ... Congenital intrinsic ... PT and aPTT 1. ... (DIC) c. ... #aPTT #Prolonged
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
PT and aPTT If ... aPTT are both prolonged ... affected in the intrinsic ... drugs (e.g. direct thrombin ... #aPTT #Prolonged
ISTH Scoring System for Disseminated Intravascular Coagulation (DIC) Platelet count: • Expected: Low (or normal) • Elevation
(DIC) Platelet ... platelet aggregation PT ... , aPTT: • Expected ... using INR use PT ... ISTH #Scoring #diagnosis
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
Thrombocytopenia • Prolonged ... PT/PTT • Low ... • Increased thrombin ... Fibrinogen: ↓ • PT ... #diagnosis #causes
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
- Differential Diagnosis ... inhibitor of a coagulation ... prolonged after ... disease • Acute DIC ... warfarin, direct thrombin
The coagulation cascade is shown, separated into different phases with their endogenous and pharmacological inhibitors shown.
The coagulation ... along with FXIIa (intrinsic ... #Coagulation #Cascade ... #clot #PT #PTT ... #diagnosis #models
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