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hematology anticoagulation coagulation aptt causes differential abnormal anticoagulant bleeding bruising cascade clot dabigatran dic disseminated doac edoxaban hemostasis heparin hepatic
Effect of Anticoagulants on Coagulation Tests PT / INR, aPTT, Anti-Xa Activity, Activated Clotting Time, Thrombin Time,
Effect of Anticoagulants ... Coagulation Tests PT ... Clotting Time, Thrombin ... Rivaroxaban Apixaban ... #Diagnosis #Laboratory
The coagulation cascade is shown, separated into different phases with their endogenous and pharmacological inhibitors shown.
Thrombin, then primes ... #clot #PT #PTT ... #diagnosis #models ... anticoagulation #anticoagulant ... #inhibitor #Apixaban
Effect of Direct Oral Anticoagulants on Hemostatic Tests Horizontal bars correspond to the approximate range of detectability
Effect of Direct ... Oral Anticoagulants ... , rixaroxaban, apixaban ... clotting time; TT = thrombin ... #testing #aptt
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
- Rivaroxaban, apixaban ... heparin - Other anticoagulants ... drugs e.g. direct thrombin ... Supratherapeutic warfarin effect ... Prolonged #Causes #diagnosis
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
- Differential Diagnosis ... coagulation, or defects ... fibrinogen levels, and testing ... warfarin, direct thrombin ... #Differential #Diagnosis
Commonly Observed Laboratory Findings in Hepatic / Liver Failure - Elevated conjugated and unconjugated bilirubin -
Commonly Observed Laboratory ... unconjugated bilirubin - Defects ... liver glycogen stores ... - Prolonged PT ... #Diagnosis #Testing
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
• Increased thrombin ... venipuncture sites Laboratory ... significant fibrin clot ... Reduction of pro/anticoagulants ... #Coagulation #diagnosis
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