417 results
Polyarteritis Nodosa (PAN): Pathogenesis and Clinical Findings

Medical Comorbidities Malignancies (most commonly hairy-cell leukemia)
Immunogenetic Predisposition: patient is
Viral replication causes ... endothelial cells - Palpable ... or necrotic purpura ... Diagnosis #Signs #Symptoms
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
Presentation: Systemic Symptoms ... • Progressive symptoms ... capillaritis, palpable ... tract, and often causes ... (red macules, palpable
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
Vasculitis: • Purpura ... tract, and often causes ... Presentation - Systemic Symptoms ... scleritis • Palpable ... Skin -> causing palpable
Algorithm for Diagnosis of the Petechial / Purpuric Rash

Febrile/Toxic, Palpable: 
 - Meningococcaemia, Disseminated Gonococcal Infection,
the Petechial / Purpuric ... Febrile/Toxic, Palpable ... Febrile/Toxic, Non-palpable ... Afebrile/Non-Toxic, Palpable ... Non-Toxic, Non-palpable
Causes of Purpura - Differential Diagnosis
Non-PalpabIe → Palpable
 • Thrombocytopenia (HIT, ITP/HUS), Coagulation defects (DIC, warfarin
Causes of Purpura ... Diagnosis Non-PalpabIe ... → Palpable • ... BrighamChiefs #Purpura ... #Causes #Differential
Petechial/Purpuric Rashes- THE ALGORITHMIC APPROACH 

These rashes can be especially challenging and are
associated with devastating differential
Petechial/Purpuric ... the etiology of palpable ... Palpable (raised ... the lesions are palpable ... patients with palpable
An Approach to the Unknown Rash: Petechial-Purpuric Rash 
#Diagnosis #Dermatology #Petechial #Purpura #Purpuric #Rash #Palpable #Algorithm
Rash: Petechial-Purpuric ... Dermatology #Petechial #Purpura ... #Purpuric #Rash ... #Palpable #Algorithm
Causes of Purpura - Differential Diagnosis
Disruption in Vascular Integrity: 
 • Trauma, Infection, Vasculitis, Drug induced
Causes of Purpura ... C), Pigmented purpuric ... BrighamChiefs #Purpura ... #nonpalpable #palpable ... #Causes #Differential
Pulmonary Renal Syndromes - OnePager Summary
Autoimmune ANCA vasculitis (AAV): GPA (granulomatous with polyangiitis), EGPA (eosinophilic granulomatosis
• Cutaneous: palpable ... purpura 2/2 vasculitis ... or serologies + symptoms ... Goodpasture's cause ... hematuria, RBC casts
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
disorders, or other causes ... OF NON-PALPABLE ... • Secondary Causes ... OF PALPABLE PURPURA ... #rheumatology #palpable