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Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
Diagnosis Framework ... Presentation: Systemic Symptoms ... sign of cutaneous ... • Progressive symptoms ... ) • Palpable purpura
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
- Differential Diagnosis ... Presentation - Systemic Symptoms ... scleritis • Palpable ... sign of cutaneous ... Skin -> causing palpable
Polyarteritis Nodosa (PAN): Pathogenesis and Clinical Findings

Medical Comorbidities Malignancies (most commonly hairy-cell leukemia)
Immunogenetic Predisposition: patient is
endothelial cells - Palpable ... or necrotic purpura ... Pathophysiology #Diagnosis ... #Signs #Symptoms ... #Vasculitis
Behçet's Syndrome
Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy
Epidemiology:
 • Young
multiforme-like lesions, palpable ... purpura, Pathergy ... meningitis), MCC CNS symptoms ... #management #signs ... #symptoms #rheumatology
Algorithm for Diagnosis of the Petechial / Purpuric Rash

Febrile/Toxic, Palpable: 
 - Meningococcaemia, Disseminated Gonococcal Infection,
Algorithm for Diagnosis ... Febrile/Toxic, Palpable ... - Autoimmune Vasculitis ... Non-Toxic, Non-palpable ... Rash #Algorithm #Diagnosis
Petechial/Purpuric Rashes- THE ALGORITHMIC APPROACH 

These rashes can be especially challenging and are
associated with devastating differential
the etiology of palpable ... Palpable (raised ... in vasculitic diseases ... lesions may have a vasculitis ... as autoimmune vasculitis
Causes of Purpura - Differential Diagnosis
Non-PalpabIe → Palpable
 • Thrombocytopenia (HIT, ITP/HUS), Coagulation defects (DIC, warfarin
Causes of Purpura ... - Differential Diagnosis ... BrighamChiefs #Purpura ... #Differential #Diagnosis ... #vasculitis
Causes of Purpura - Differential Diagnosis
Disruption in Vascular Integrity: 
 • Trauma, Infection, Vasculitis, Drug induced
Causes of Purpura ... - Differential Diagnosis ... #nonpalpable #palpable ... #Differential #Diagnosis ... #vasculitis
Petechiae/Purpura - Diagnostic Algorithm. Pathophysiology: 1) Represent the passage of erythrocytes from the intravascular to extravascular
Petechiae/Purpura ... - Diagnostic Algorithm ... trauma, infection, vasculitis ... pulmonary #Diagnosis ... Rash #Petechiae #Purpura
Vasculitis: In this instance, idiopathic with palpable purpura.

Charlie Goldberg, M.D. - UCSD Catalog of Clinical Images

#Clinical
Vasculitis: In this ... idiopathic with palpable ... purpura. ... #Idiopathic #Palpable ... #Purpura #UCSDH