50 results
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... Extravascular Causes ... ) - HELLP syndrome ... thrombocytopenic purpura ... ) (e.g. lupus, CLL
Multiple Myeloma and Monoclonal Gammopathies
C - HyperCalcemia- calcium > 11 mg/dL / >1 mg/dL the ULN
R
Causes of false- ... diseases, CML, ... plasmacytoma, POEMs syndrome ... Gammopathies #MGUS #diagnosis ... #hematology #oncology
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary
myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Myelodysplastic Syndrome ... old, ~10,000 new cases ... Allogeneic stem cell ... #Management #treatment ... #hematology #oncology
Leukemias Overview: ALL, CML, AML, APML, CLL

Acute leukemias > 20% blasts in the peripheral blood smear
extramedullary disease ... -> AML: Blast crises ... develop leukostasis syndrome ... • Tumor lysis syndrome ... #Oncology #Diagnosis
Chronic Lymphocytic Leukemia - Summary

Cancer affecting lymphocytes/Mature B cell neoplasm
 • Lymphocytes accumulate in large numbers
Orange or Hep C Clinical ... cells can indicate disease ... microglobulin Treatment ... #workup #oncology ... #hematology
Dermatologic Manifestations of Granulomatosis with Polyangiitis (GPA)

Skin involvement in granulomatosis with polyangiitis (GPA) is common and
GPA causes disease ... Rarely dominate the clinical ... Differential Diagnosis ... • Goodpasture syndrome ... #rheumatology
Behçet's Syndrome
Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy
Epidemiology:
 • Young
association • M > F Clinical ... lesions, palpable purpura ... (Clinical Dx). ... Arthritis, AS Treatment ... signs #symptoms #rheumatology
Non-HCV infectious mixed cryoglobulinemia vasculitis - Diagnosis, causes and management - French Vasculitis Study Group

< 5%
, causes and management ... cryoglobulinemia vasculitis Clinical ... involvement with purpura ... neuropathy Treatment ... with refractory disease
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
Clinical Presentation ... (Petechial or purpuric ... Treatment: • Corticosteroids ... #Diagnosis #Management ... #Hematology #Rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
- Differential Diagnosis ... tract, and often causes ... , and ocular inflammation ... • Cogan Syndrome ... #rheumatology #