8 results
Aplastic Anemia - Overview

Who?
• M = F
• 3 peaks:	1) Childhood	2) 15-25 years	3) >60 years

What?
• Aplastic anemia
Constitutional Syndromes ... and petechiae Causes ... Constitutional Syndromes ... marrow-failure syndromes ... #oncology #hematology
Vibrio Vulnificus skin infection
Cirrhosis w/recent consumption of raw oysters w/rapidly evolving rash. 
Vibrio vulnificus part of
rapidly evolving rash ... marine microbiota & causes ... hemochromatosis, hemolytic anemia ... immunosuppressive meds ... #cellulitis #dermatology
Acute Retroviral Syndrome
Acute Retroviral Syndrome is the symptomatic presentation of acute human immunodeficiency virus infection

 •
(28%) • Skin rash ... during transient CD4 ... enzymes ↑ • Mild anemia ... Epstein-Barr virus (EBV ... progression by slowing CD4
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
Cold Agglutinin Syndrome ... • Symptoms of anemia ... hemolysis • C3↓ C4 ... - Mycoplasma, EBV ... #hematology #diagnosis
Idiopathic CD4 Lymphopenia (ICL) / Lymphocytopenia 

DIAGNOSTIC CRITERIA FOR ICL
 • Persistent CD4 T-cell lymphopenia
 •
• Persistent CD4 ... chemotherapy) • Genetic syndromes ... EBV. CMV. ... ICL #diagnosis #hematology ... #Differential #Causes
Causes of Neutropenia - Differential Diagnosis
Neonate:
 - Infection - by far the most common cause
 -
neutropenia, Kostmann syndrome ... Chediak-Higashi syndrome ... replacing the BM ... Megaloblastic anemia-rare ... #hematology
Leukemias Overview: ALL, CML, AML, APML, CLL

Acute leukemias > 20% blasts in the peripheral blood smear
-> AML: Blast crises ... develop leukostasis syndrome ... - infiltrates (anemia ... • Tumor lysis syndrome ... #Leukemia #Hematology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4)

Work-up of an Elevated Globulin Gap:
•
Causes of Monoclonal ... changes (POEMS syndrome ... acute HIV, HBV, EBV ... Thalassemia, Sickle cell anemia ... • Other causes