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diagnosis hematology oncology vasculitis anemia cd4 classification dermatologic globulin granulomatosis icl idiopathic joint lymphocytopenia lymphopenia management monoclonal neutropenia nonpalpable pain
Dermatologic Manifestations of Granulomatosis with Polyangiitis (GPA) Skin involvement in granulomatosis with polyangiitis (GPA) is common and
Polyangiitis (GPA ... polyangiitis (GPA ... GPA causes disease ... #Polyangiitis #GPA ... #dermatology #rash
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Purpura - Differential ... vasculitis - GPA ... #Diagnosis #hematology ... #rheumatology # ... #nonpalpable #dermatology
Skin Conditions Associated with Joint Pain Rash • Human parvovirus B19 infection Malar rash • SLE • Human parvovirus B19 infection •
Sarcoidosis • GPA ... Antiphospholipid-antibody syndrome ... Sarcoidosis #dermatology ... #skin #rashes #differential ... #diagnosis #rheumatology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Constitutional Syndromes ... Anemia Clinical ... and petechiae Causes ... Constitutional Syndromes ... Anemia #oncology #hematology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
> PR3 60% • GPA ... tract, and often causes ... mucositis - Rash ... • ANCA (Dx: GPA ... #diagnosis #rheumatology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Globulin - Protein Gap ... changes (POEMS syndrome ... gastric tumors • Hematology ... #ProteinGap #differential ... #diagnosis #hematology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
capillary leak syndrome ... Pseudohyponatremia • ↓anion gap ... Thrombosis in vascular beds-renal ... Paraproteinemias #Hematology ... #Monoclonal #Differential
Causes of Neutropenia - Differential Diagnosis Neonate: - Infection - by far the most common cause -
- Differential ... neutropenia, Kostmann syndrome ... Chediak-Higashi syndrome ... white blood cell aplasia ... #hematology
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Vasculitis - Differential ... , mucositis • Rash ... MPO > PR3 60/ GPA ... tract, and often causes ... #Diagnosis #Rheumatology
Idiopathic CD4 Lymphopenia (ICL) / Lymphocytopenia DIAGNOSTIC CRITERIA FOR ICL • Persistent CD4 T-cell lymphopenia •
chemotherapy) • Genetic syndromes ... Heme (lymphoma. aplasia ... ICL #diagnosis #hematology ... #Differential # ... Causes #lymphocytopenia
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