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diagnosis hematology syndrome rheumatology oncology product reactions antinxp2 antinxp2dm aortic coagulation dermatologic dermatomyositis dic dissection disseminated dress encephalopathy gpa granulomatosis
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
) Classification ... Workup: • Full Blood ... number of sites of disease ... Lymphoma Treatment ... #management
Dermatologic Manifestations of Granulomatosis with Polyangiitis (GPA) Skin involvement in granulomatosis with polyangiitis (GPA) is common and
GPA causes disease ... Maculopapular rash ... disease • Non-Hodgkin ... vasculitis (inflamed blood ... #rash #diagnosis
Streptococcal Toxic Shock Syndrome (STSS) Complication of invasive GAS disease characterized by shock & MOF → occurs
of invasive GAS disease ... GAS in 30% of cases ... body site (i.e., blood ... erythematous macular rash ... #management #diagnosis
Hemophilia - Diagnosis and Management Diagnosis: • Consistent bleeding history (unless screening for disease in family members
Diagnosis and Management ... screening for disease ... normal in mild cases ... Avoid meds that ... #treatment #hematology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Phagocytosis of blood ... Hemopathies+++: Hodgkin ... Drugs, Unknown cause ... Treatment: • ... Lymphohistiocytosis #diagnosis #management
Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) Definition: • Severe adverse drug reaction, characterized by
extensive skin rash ... Edema in 70% of cases ... : symptomatic treatment ... • Severe disease ... DRESS #Syndrome #dermatology
Aortic Dissection Pearls Aortic dissection is caused by a tear in the tunica intima, the innermost layer
dissection is caused ... • Aortic valve disease ... deficit • Shock Treatment ... ~60 • Control blood ... Dissection #diagnosis #management
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
ABO incompatible blood ... • Severe Liver Disease ... Treat primary cause ... #treatment #management ... #hematology
Blood Transfusion Reactions Immune Mediated: • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
maculopapular rash ... Causes purpura & ... TRALI): Leading cause ... Transfusion #diagnosis #management ... #hematology #reactions
Blood Product Transfusions One Pager Summary Type and screen - determines blood type and detects in recipient
maculopapular rash ... Causes purpura & ... TRALI): Leading cause ... Transfusions #diagnosis #management ... #hematology #reactions
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