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diagnosis lupus druginduced systemic activation antinxp2 antinxp2dm arteritis cerebritis cns comparison dermatology dermatomyositis differential dil gca giantcell gravis hematology macrophage
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Systemic Lupus Erythematosus ... Manifestations: Malar rash ... Positive in 60-80% of cases ... life-threatening • Treatment ... #Summary #rheumatology
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
(SLE) Clinical ... autoantibodies that will cause ... #SLE #CNS #neurology ... #rheumatology # ... cerebritis #diagnosis #management
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
NPSLE rare, Malar rash ... Systemic Lupus Erythematosus ... Manifestations: Malar rash ... comparison #table #rheumatology ... #diagnosis #management
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Petechial or purpuric rash ... [SLE], AOSD) • ... Treatment: • Corticosteroids ... Syndrome #Diagnosis #Management ... #Hematology #Rheumatology
Myasthenia Gravis Overview Myasthenia Gravis is an autoimmune disorder of the postsynaptic neuromuscular junction. Ab to
rheumatoid arthritis, SLE ... Myasthenia Crises ... immunosuppressants - Meds ... Gravis #diagnosis #management ... #neurology
Giant cell arteritis (GCA) Giant cell arteritis (GCA) definition: Most common systemic inflammatory vasculitis in older adults
with systemic, neurologic ... (Cornelia NEJM ... Treatment of GCA ... them, but urgent rheumatology ... Symptoms #Diagnosis #Management
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
diseases, such as SLE ... ischemia • Skin: Erythematous ... , mucositis • Rash ... tract, and often causes ... Differential #Diagnosis #Rheumatology
Drug Induced Lupus (DIL) • Epidemiology: -10% of all lupus cases, drug-dependent, 4:1 to 1:1 F:M
NPSLE rare, Malar rash ... is rare in DIL, SCLE-DIL ... Discontinuation of causal ... DrugInduced #Lupus #DIL #rheumatology ... #management
Anti-NXP-2 Dermatomyositis What? DM with generalized subcutaneous edema Pts have more myalgias, more severe weakness, and an increased prevalence
rash on the face ... Muscle atrophy may cause ... positive patients Treatment ... Dermatomyositis #diagnosis #management ... #rheumatology #
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