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diagnosis syndrome lupus dermatology druginduced hematology hemophagocytic hlh lymphohistiocytosis summary activation adultonset antinxp2 antinxp2dm cardiology cardiomyopathy dermatomyositis disease encephalopathy erythematosus
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
to 1:1 F:M • Clinical ... NPSLE rare, Malar rash ... SCLE-DIL (terbinafine ... #comparison #table ... #rheumatology #
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
40, F:M 9:1 • Clinical ... Manifestations: Malar rash ... versus DIL • ... life-threatening • Treatment ... #Summary #rheumatology
Adult-Onset Still's Disease Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia + Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
Still's Disease Clinical ... arthritis, Skin rash ... Complications: MAS ... Disease #diagnosis #management ... #treatment #rheumatology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Petechial or purpuric rash ... erythematosus [SLE ... Treatment: • Corticosteroids ... Syndrome #Diagnosis #Management ... #Hematology #Rheumatology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
accumulation of clinical ... Autoimmune diseases: SLE ... Treatment: • ... Lymphohistiocytosis #diagnosis #management ... #rheumatology
Drug Induced Lupus (DIL) • Epidemiology: -10% of all lupus cases, drug-dependent, 4:1 to 1:1 F:M
to 1:1 F:M • Clinical ... NPSLE rare, Malar rash ... SCLE-DIL (terbinafine ... #rheumatology # ... #management
SAPHO Syndrome Summary What? SAPHO syndrome is a rare chronic inflammatory disorder of bone, joint, and skin characterized
Rheumatic pain Clinical ... Rule out other causes ... and lower jaw Treatment ... SAPHO #Syndrome #Rheumatology ... #diagnosis #management
Posterior Reversible Encephalopathy Syndrome (PRES) Overview Clinico-Radiological Syndrome, characterized by: • Headache • Seizures • Altered mental
brain PRES Clinical ... PRES-Associated Clinical ... the underlying cause ... • Treatment of ... Syndrome #diagnosis #management
Polymyalgia Rheumatica (PMR) Diagnosis and Management Summary WHAT? • Polymyalgia rheumatica (PMR) is a common systemic inflammatory
Diagnosis and Management ... disease of unknown cause ... greater than 6 dL ... TREATMENT: • The ... #Rheumatology
Peripartum Cardiomyopathy - Summary 1. Definition • Towards the end of pregnancy to 5 months postpartum
exclude other causes ... Clinical • Under-recognized ... orthopnea, PND, LE ... teratogenic GDMT meds ... #cardiology #treatment
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