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rheumatology dermatology differential druginduced classification clinical complications dil erythematosus eschar manifestations mucocutaneous mucormycosis papulosquamous pathophysiology signs skin summary symptoms systemic
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
cases, drug-dependent ... Discontinuation of causal ... Positive in 60-80% of cases ... #sle #comparison ... #rheumatology #diagnosis
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
(SLE) - Diagnosis ... and Management ... Manifestations: Malar rash ... Positive in 60-80% of cases ... Erythematosus #Diagnosis
Vesiculobullous Skin Rash - Differential Diagnosis Algorithm Vesicles Fragile/EasiIy Ruptured - Intraepidermal blisters, possibly crusts/erosions - Inflammatory
Vesiculobullous Skin Rash ... Algorithm Vesicles ... Bullous systemic lupus ... Vesiculobullous #SkinRash ... #Algorithm #causes
Lupus (SLE): Mucocutaneous Manifestations • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
Lupus (SLE): Mucocutaneous ... response -> Subacute cutaneous ... hair follicles -> causes ... Malar (butterfly) Rash ... pathophysiology #diagnosis
Papulosquamous Skin Rash - Differential Diagnosis Algorithm Erythrematous or violaceous papules & plaques with overlying scale •
Papulosquamous Skin Rash ... - Differential Diagnosis ... soles • Discoid Lupus ... Papulosquamous #SkinRash ... #Algorithm #causes
Drug Induced Lupus (DIL) • Epidemiology: -10% of all lupus cases, drug-dependent, 4:1 to 1:1 F:M
cases, drug-dependent ... NPSLE rare, Malar rash ... is rare in DIL, SCLE-DIL ... #rheumatology #diagnosis ... #treatment #management
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
tract, and often causes ... mucositis - Rash ... such as systemic lupus ... strong sign of cutaneous ... vasculitis, and SLE
Cutaneous Mucormycosis Eschar 30 M HIV cd4 10 VL 30k traumatic injury of arm few months ago
Diagnosis? ... mucor cases may ... malnutrition, HIV, SLE ... therapy), some cases ... skin #clinical #photo
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