13 results
Vesiculobullous Skin Rash - Differential Diagnosis Algorithm
Vesicles Fragile/EasiIy Ruptured - Intraepidermal blisters, possibly crusts/erosions
 - Inflammatory
Vesiculobullous Skin Rash ... Bullous systemic lupus ... drug eruption #Vesicular ... Vesiculobullous #SkinRash ... #causes
Petechiae/Purpura - Diagnostic Algorithm. Pathophysiology: 1) Represent the passage of erythrocytes from the intravascular to extravascular
Purpura - Diagnostic Algorithm ... disruption of vascular ... . 2) When cutaneous ... commonly renal and ... #Dermatology #Rash
Skin Ulcers by Etiology - Differential Diagnosis Algorithm
Physical:
 • Trauma
 • Pressure
 • Radiation
Vascular:
 • Arterial
• Radiation Vascular ... insufficiency • Vasculitis ... Mycosis fungoides (cutaneous ... Ulcers #ulcerative #skinrash ... #causes
Drug Induced Lupus vs SLE
Drug Induced Lupus (DIL):
 • Epidemiology: -10% of all lupus cases, drug-dependent,
cases, drug-dependent ... NPSLE rare, Malar rash ... Discontinuation of causal ... Positive in 60-80% of cases ... #sle #comparison
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
often causes arthritis ... bullous or vesicular ... mucositis - Rash ... such as systemic lupus ... strong sign of cutaneous
Lupus (SLE): Mucocutaneous Manifestations

 • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
response -> Subacute cutaneous ... hair follicles -> causes ... plugging -> Discoid Rash ... Malar (butterfly) Rash ... Livedo Reticularis, Vasculitis
Causes of Petechial Rash - Differential Diagnosis Algorithm

Pinpoint areas (less than 2 mm) of hemorrhage, which
Causes of Petechial ... Diagnosis Algorithm ... Disruptions in vascular ... (lupus, RA, Sjogren's ... for hepatitis B and
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• They can cause ... Cryoglobulins Cause ... Vascular Sludging ... Henoch-Schönlein purpura) • Cutaneous ... (e.g. systemic lupus
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
Strong sign of cutaneous ... bullous or vesicular ... , mucositis • Rash ... often causes arthritis ... (lower legs), cutaneous
Papulosquamous Skin Rash - Differential Diagnosis Algorithm
Erythrematous or violaceous papules & plaques with overlying scale
 •
Papulosquamous Skin Rash ... Differential Diagnosis Algorithm ... soles • Discoid Lupus ... Papulosquamous #SkinRash ... #causes