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diagnosis rheumatology differential erythematosus lupus systemic activation amiodarone autoantibodies autoimmune classification hematology macrophage mas mimickers myopathy myositis pulmonary sarcoidosis toxicity
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
) General: Fever ... effusion, Restrictive lung ... Demyelinating syndromes ... erythematosus #signs ... #symptoms #diagnosis
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
69% - Malar rash ... 40% - Fever 36% ... Myositis 4% - Lung ... autoantibodies #signs ... #symptoms #mimickers
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
weight loss, and fever ... extremities Drug Induced ... Lupus: • Symptoms ... to: Arthritis, Fever ... Antihistone: Drug induced
Sarcoidosis - Diagnosis and Management Summary Epidemiology 1) High incidence in Scandinavian countries (11-24 cases per 100,000 individuals
Diagnosis and Management ... granulomas within the lungs ... General: fever, ... Sarcoidosis #Diagnosis #Management ... #Signs #Symptoms
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Petechial or purpuric rash ... ) • Heart, lung ... erythematosus [SLE ... Sepsis • Drug-induced ... #Diagnosis #Management
Amiodarone Induced Lung Toxicity Summary Who? • 5% of patients • Dose ≥ 400 mg per day How? Possible
respiratory distress syndrome ... gradually with symptoms ... Fever 4. ... Improvement in symptoms ... Pulmonary #diagnosis #management
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
• Hydralazine-Induced ... mucositis - Rash ... Presentation - Systemic Symptoms ... purpura: strong sign ... vasculitis, and SLE
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
thyroid, drug-induced ... : • Gottron rash ... papules and Gottron sign ... ) • Shawl sign ... : Fever, joint pain
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