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diagnosis differential management sle syndrome activation antimda5 antimda5dm antinxp2 antinxp2dm compared dress druginduced erythemas hematology joint macrophage mas myopathies myopathy
Skin Conditions Associated with Joint Pain Rash • Human parvovirus B19 infection Malar rash • SLE • Human parvovirus B19 infection •
Joint Pain Rash ... infection Malar rash ... lesions • Discoid lupus ... Sarcoidosis #dermatology ... differential #diagnosis #rheumatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
evidence of (fatigue, rash ... eruption - Butterfly rash ... Photosensitive rash ... Still disease, dermatomyositis ... Photosensitivity • Malar rash
ANTI-MDA5 DERMATOMYOSITIS Cutaneous manifestations: • Periorbital heliotrope (blue-purple) rash with edema • Erythematous rash on the face, or the
(blue-purple) rash ... with edema • Erythematous ... rash on the face ... #rheumatology # ... dermatology #diagnosis
Myositis and Myopathies Polymyositis • Progressive, symmetric muscle weakness • Elevated CK, +Anti-Jo, +Anti-Mi2 Dermatomyositis
Anti-Jo, +Anti-Mi2 Dermatomyositis ... muscle weakness, rash ... uncommon 5-15% of lupus ... differential #diagnosis #comparison ... #rheumatology
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
NPSLE rare, Malar rash ... Erythematosus ( ... Manifestations: Malar rash ... #sle #comparison ... #table #rheumatology
DRESS Syndrome vs SJS/TEN DRESS • Latency: 2-8 weeks • Rash: Morbilliform • Mucosal involvement: 50% have
: 2-8 weeks • Rash ... : 4-28 days • Rash ... : Painful erythematous ... Syndrome #SJS #TEN #comparison ... #table #dermatology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
erythematosus ... Petechial or purpuric rash ... erythematosus [ ... Diagnosis #Management #Hematology ... #Rheumatology
Erythemas Summarized Erythema ab igne • A dermatosis that results from repeated exposure to heat (fires, heating
Rash is usually ... chronicum migrans • Rash ... Fever + facial rash ... • Evanescent rash ... Acute systemic rash
Anti-NXP-2 Dermatomyositis What? DM with generalized subcutaneous edema Pts have more myalgias, more severe weakness, and an increased prevalence
(blue-purple) rash ... with edema • Erythematous ... rash on the face ... diagnosis #management #rheumatology ... #dermatology
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