11 results
Hemolysis Classification - Intrinsic and Extrinsic Causes

Commentary: Another way to think of immune hemolysis would be
and Extrinsic Causes ... autoimmune (most of the causes ... hemolytic transfusion reactions ... Differential #Diagnosis #Causes ... #Algorithm
Summary table of types of hypersensitivity reactions. 
Type 1
 - Mediators: lgE
 - Antigen Form: Soluble
Summary table of ... Allergen-specific lgE causes ... to complement activation ... types #allergy #table ... #classification
TRALI vs TACO - Transfusion Reactions
TRALI:
 • Epidemiology: 0.1% of transfused patientsl
 • Risk factors: Critical
- Transfusion Reactions ... blood donor • Pathophysiology ... sequestration and activation ... without other cause ... diagnosis #comparison #table
Hypersensitivity Types and Their Mechanisms
Type I - lgE - Soluble antigen
 - Allergen-specific lgE antibodies bind
Complement activation ... Hypersensitivity #Types #Classification ... #Pathophysiology ... Allergy #Diagnosis #Reactions ... #Table
Type IV Hypersensitivity: Pathogenesis and clinical findings
Definition: Unique because it is entirely T-Cell mediated; exposure to
exposure to allergen causes ... Allergic reaction ... because T-Cell activation ... Allergy #Immunology #pathophysiology
Antiarrhythmics - Vaughan Williams Classification:
CLASS 1 - Sodium Channel Blockers:
 • MOA: Block fast Na+ channels
Vaughan Williams Classification ... : CLASS 1 - Sodium ... Inhibit B.adrenergic activation ... #Pharmacology #Classification ... #Classes #pathophysiology
Hypersensitivity: Definitions
 • Type I - Production of lgE Abs that bind to harmless allergens and
cell surfaces causes ... an immune reaction ... exposure to allergen causes ... because T-Cell activation ... #Types #Classification
Antiarrhythmics Pharmacology Summary
Cardiac Conduction Phases:
Phase 0 - Ventricular Depolarization:
 • Na+ channels open leading to a
Vaughan Williams Classification ... : CLASS 1 - Sodium ... Inhibit B.adrenergic activation ... #Pharmacology #Classification ... #Classes #pathophysiology
Hepatorenal Syndrome (HRS)

Definition:
• Functional, potentially reversible kidney impairment.
• Occurs in advanced liver disease: cirrhosis, severe alcoholic
Pathophysiology: ... sympathetic + ADH activation ... Exclude other AKI causes ... Classification: ... essential in all cases
Fracture Healing (and disruptors of this process)
Inflammatory Stage (0-7d)
 • Fracture disrupts local blood vessels ->
> Inflammatory reaction ... of cytokines -> activation ... Fluoroquinolones - Causes ... #msk #Staging #pathophysiology