10 results
Anaphylaxis: Pathogenesis
Anaphylaxis is a Type 1 hypersensitivity reaction
While the primary mechanism of anaphylaxis is mast cell
Anaphylaxis is a Type 1 hypersensitivity ... anaphylaxis is mast cell activation ... Inappropriate mast cell activation ... cells • ANS activation ... #Anaphylaxis #pathophysiology
Hypersensitivity Types and Their Mechanisms
Type I - lgE - Soluble antigen
 - Allergen-specific lgE antibodies bind
Hypersensitivity ... Complement activation ... sclerosis #Hypersensitivity ... #Types #Classification ... #Pathophysiology
Type IV Hypersensitivity: Pathogenesis and clinical findings
Definition: Unique because it is entirely T-Cell mediated; exposure to
Type IV Hypersensitivity ... because T-Cell activation ... Allergy #Immunology #pathophysiology
Summary table of types of hypersensitivity reactions. 
Type 1
 - Mediators: lgE
 - Antigen Form: Soluble
table of types of hypersensitivity ... to complement activation ... Graft rejection #hypersensitivity ... allergy #table #classification
Antiarrhythmics - Vaughan Williams Classification:
CLASS 1 - Sodium Channel Blockers:
 • MOA: Block fast Na+ channels
Vaughan Williams Classification ... Inhibit B.adrenergic activation ... #Pharmacology #Classification ... #Classes #pathophysiology
Lymphomas and Lymphoproliferative Disorders - Differential Diagnosis Algorithm
Hodgkin Lymphoma ~40% - Characteristic For Reed-Sternberg (RS) Cells
Differential Diagnosis Algorithm ... Lymphoproliferative #Disorders #Classification ... #pathophysiology ... #differential #algorithm
Antiarrhythmics Pharmacology Summary
Cardiac Conduction Phases:
Phase 0 - Ventricular Depolarization:
 • Na+ channels open leading to a
Vaughan Williams Classification ... Inhibit B.adrenergic activation ... #Pharmacology #Classification ... #Classes #pathophysiology
Hepatorenal Syndrome (HRS)

Definition:
• Functional, potentially reversible kidney impairment.
• Occurs in advanced liver disease: cirrhosis, severe alcoholic
Pathophysiology: ... sympathetic + ADH activation ... Classification:
Hypersensitivity: Definitions
 • Type I - Production of lgE Abs that bind to harmless allergens and
Hypersensitivity ... because T-Cell activation ... #Hypersensitivity ... Reactions #Types #Classification
Functional GI Disorders in IBD - IBD Algorithm

Background:
 • 25-40% of IBD in remission have IBS
Disorders in IBD - IBD Algorithm ... narcotic use FGID Pathphysiology ... microbiome • Visceral hypersensitivity ... IBDAlgorithm #IBD #Algorithm